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@INPROCEEDINGS{Kops:908202,
      author       = {Kops, E. Rota and Hautzel, H. and Herzog, H. and Lerche, C.
                      and Shah, N. J.},
      title        = {{A}ttenuation {C}orrection of {C}erebellum in {PET}/{MR}
                      {D}ata},
      reportid     = {FZJ-2022-02453},
      year         = {2017},
      abstract     = {Abstract:Most approaches of modelling neuroreceptor PET
                      studies apply the cerebellum as reference area. Therefore,
                      it is mandatory that the respective attenuation correction
                      (AC) method for reconstructing the emission data is most
                      appropriate regarding cerebellar areas. PET data from PET/MR
                      scanners require alternative AC methods. These ought to be
                      tested with respect to the performance within the
                      cerebellum. This study aimed to compare various AC methods
                      for PET/MR data focussing on the cerebellum. Data of 16
                      subjects undergoing 18 FDG imaging in the Siemens
                      3TMR-BrainPET scanner and a whole head CT scan at the same
                      day were used. The latter were transformed to CT-based
                      attenuation maps (AM CT ). The MR images were used to obtain
                      AMs using the Boston-MGH method (AM MGH ), the London-UCL
                      method (AM UCL ), the CT-template-based (AM CT-Juel ) and
                      Tx-template-based (AM Tx-Juel ) Juelich methods. BrainPET
                      emission data were reconstructed with the five AM s . Using
                      the SUIT tool the cerebellum was extracted from the MR
                      images and normalized to a cerebellum VOI atlas. The
                      cerebellum of the PET data was extracted by applying the
                      same parameters. Correlation plots with regression
                      equations, coefficients of determination R 2 , normalized
                      and absolute normalized errors (NErr) between AM CT and the
                      other four AM s were calculated. The values of cerebellar
                      NErr varied to a high extent between the four AC methods. In
                      one subject AM MGH showed the lowest NErr $(3.03±1.60\%),$
                      in three participants the AMUCL performed best (NErr from
                      $-0.13±2.33\%$ to $0.91±2.93\%),$ in three others the AM
                      Tx-Juel had the best results (NErr from $-1.24±3.01\%$ to
                      $0.86±2.07\%),$ while for the remaining seven subjects the
                      AM CT-Juel performed best (NErr from $-2.08±0.94\%$ to
                      $7.98±3.43\%).$ Our results demonstrate that the
                      quantitation of radiotracer uptake in the cerebellum is very
                      susceptible to the respective attenuation correction applied
                      to the PET data. This, in turn, has to be considered in
                      neuroreceptor modelling studies which rely on the cerebellum
                      as reference.},
      month         = {Oct},
      date          = {2017-10-21},
      organization  = {2017 IEEE Nuclear Science Symposium
                       and Medical Imaging Conference
                       (NSS/MIC), Atlanta (GA), 21 Oct 2017 -
                       28 Oct 2017},
      cin          = {INM-4 / INM-11 / JARA-BRAIN},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      I:(DE-Juel1)VDB1046},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)1},
      doi          = {10.1109/NSSMIC.2017.8532870},
      url          = {https://juser.fz-juelich.de/record/908202},
}