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@MISC{Lohmann:908207,
      author       = {Lohmann, P. and Stavrinou, P. and Lipke, K. and Bauer, E.
                      K. and Ceccon, G. and Werner, J. and Fink, G. R. and Shah,
                      N. J. and Langen, K. and Galldiks, N.},
      title        = {{P}01.014 {S}patial correlation of {FET} uptake and {MRI}
                      contrast enhancement in newly diagnosed glioblastoma
                      patients prior to treatment},
      issn         = {1523-5866},
      reportid     = {FZJ-2022-02458},
      year         = {2018},
      abstract     = {BackgroundA complete glioma resection is known to prolong
                      survival. Contrast enhancement (CE) in MRI is usually the
                      target for resection but the solid tumor mass may extend
                      beyond the area of CE. It has been demonstrated that amino
                      acid PET can detect tumor parts showing no CE in MRI. We
                      systematically investigated the volumetric correlation of
                      amino acid uptake with PET and CE in MRI in newly diagnosed
                      and untreated glioblastoma patients.Material and
                      MethodsPreoperatively, 26 patients were examined by
                      O-(2-[18F]-fluoroethyl)-L-tyrosine (FET) PET and
                      contrast-enhanced MRI. Enhancing tumor areas on MRI were
                      manually segmented on each transverse section and the sum of
                      the areas was multiplied by the slice thickness to obtain
                      contrast-enhancing volumes. The calculation of FET PET tumor
                      volumes was based on an auto-contouring process using a
                      tumor-to-brain ratio of 1.6 or more. For volumetric
                      comparison, the Dice and Jaccard spatial similarity
                      coefficients (DSC; JSC) and the percentage of overlapping
                      volumes (OV) were calculated. Postoperatively, a
                      glioblastoma was confirmed neuropathologically in all
                      patients.ResultsFET PET tumor volumes were significantly
                      larger than contrast-enhancing volumes (26.7 ± 13.4 mL vs.
                      15.1 ± 11.5 mL; P=0.002). The spatial similarity between
                      FET PET and CE was poor (mean DSC, 0.44 ± 0.18; mean JSC,
                      0.30 ± 0.14). Additionally, approximately one quarter of
                      patients (n=7) showed a low spatial overlap (mean OV, 36 ±
                      $18\%).ConclusionThe$ present data suggest that the
                      metabolic tumor volume as detected by FET PET is
                      substantially underestimated by CE. Information derived from
                      both imaging modalities should be integrated for the routine
                      management of patients with newly diagnosed glioblastoma.},
      cin          = {INM-4 / INM-11 / JARA-BRAIN / INM-3 / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      I:(DE-Juel1)VDB1046 / I:(DE-Juel1)INM-3-20090406 /
                      I:(DE-Juel1)INM-5-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)4},
      doi          = {10.1093/neuonc/noy139.056},
      url          = {https://juser.fz-juelich.de/record/908207},
}