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@ARTICLE{Kondrat:908530,
      author       = {Kondrat, Svyatoslav and Krauss, Ulrich and von Lieres,
                      Eric},
      title        = {{E}nzyme co-localisation: {M}echanisms and benefits},
      journal      = {Current research in chemical biology},
      volume       = {2},
      issn         = {2666-2469},
      address      = {[Amsterdam]},
      publisher    = {Elsevier B.V.},
      reportid     = {FZJ-2022-02666},
      pages        = {100031 -},
      year         = {2022},
      abstract     = {Co-localising enzymes can drastically affect their
                      properties, such as stability, specificity, and activity,
                      thus influencing reaction kinetics. In this review, we
                      present a brief overview of the main methods developed for
                      enzyme immobilisation, co-localisation, and conjugation and
                      discuss how and why they affect the enzyme properties. We
                      also describe the effects emerging from bringing two
                      sequential enzymes of a cascade reaction together,
                      particularly if and when it speeds up reaction velocity.
                      Furthermore, we discuss enzyme compartmentalisation, or
                      clustering of several enzymes of a cascade, and present
                      theoretical approaches developed to optimise synthetic
                      enzyme clusters. We also point out the plenitude of open
                      questions, which exist despite the enormous research effort
                      channelled into understanding enzyme co-localisation.},
      cin          = {IBG-1 / IMET},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBG-1-20101118 / I:(DE-Juel1)IMET-20090612},
      pnm          = {2171 - Biological and environmental resources for
                      sustainable use (POF4-217)},
      pid          = {G:(DE-HGF)POF4-2171},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.crchbi.2022.100031},
      url          = {https://juser.fz-juelich.de/record/908530},
}