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@INPROCEEDINGS{Bauer:908572,
      author       = {Bauer, E. K. and Stoffels, G. and Blau, T. and
                      Reifenberger, G. and Werner, J. M. and Lohmann, P. and Rapp,
                      M. and Fink, G. R. and Langen, K. and Galldiks, N.},
      title        = {{P}14.29 {P}rediction of overall survival in patients with
                      malignant glioma using dynamic
                      {O}-(2-[18{F}]-fluoroethyl)-{L}-tyrosine {PET}},
      issn         = {1523-5866},
      reportid     = {FZJ-2022-02696},
      year         = {2019},
      abstract     = {AbstractBACKGROUNDCharacterization of gliomas according to
                      the revised World Health Organization (WHO) classification
                      of 2016 has gained major importance regarding
                      prognostication. The present study aimed at exploring the
                      prognostic value of dynamic
                      O-(2-[18F]-fluoroethyl)-L-tyrosine (FET) PET in newly
                      diagnosed and molecularly defined astrocytic high-grade
                      glioma (HGG) of the WHO grades III or IV.MATERIAL AND
                      METHODSBefore initiation of treatment, dynamic FET PET
                      imaging was performed in patients with newly diagnosed
                      glioblastoma (GBM) and anaplastic astrocytoma (AA). Static
                      FET PET parameters such as maximum and mean tumor/brain
                      ratios (TBRmax/mean), as well as the dynamic FET PET
                      parameters time-to-peak (TTP) and slope, were obtained. The
                      predictive ability of FET PET parameters was evaluated with
                      regard to the overall survival (OS). Using ROC analyses,
                      threshold values for FET PET parameters were obtained.
                      Subsequently, univariate Kaplan-Meier and multivariate Cox
                      regression survival analyses were performed to assess their
                      predictive power for OS.RESULTSSixty patients (45 GBM, 15
                      AA) of two university centers were retrospectively
                      identified. Patients with a methylated MGMT promoter as well
                      as with an IDH mutation had a significantly longer OS (both
                      P<0.001). Furthermore, ROC analysis revealed in IDH-wildtype
                      HGG (n=45) that a TTP>25 minutes (AUC, 0.90; sensitivity,
                      $90\%;$ specificity, $87\%;$ P<0.001) was highly prognostic
                      for a longer OS (29 vs. 12 months; P<0.001). Besides a
                      complete resection and a methylated MGMT promoter, TTP
                      remained significant in the multivariate survival analysis
                      (P=0.002, P=0.016, and P=0.003, respectively), indicating an
                      independent predictor for OS. In contrast, both TBRmax and
                      TBRmean were not prognostic (AUC, 0.37 and 0.32,
                      respectively).CONCLUSIONData suggest that within the
                      subgroup of patients with newly diagnosed and untreated
                      IDH-wildtype GBM and AA, dynamic FET PET additionally allows
                      the identification of patients with an improved OS.},
      month         = {Sep},
      date          = {2019-09-19},
      organization  = {14th Meeting of the European
                       Association of Neuro-Oncology, Lyon
                       (France), 19 Sep 2019 - 22 Sep 2019},
      cin          = {INM-4 / IEK-5 / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)IEK-5-20101013 /
                      I:(DE-Juel1)INM-3-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)1},
      UT           = {WOS:000493085900266},
      doi          = {10.1093/neuonc/noz126.264},
      url          = {https://juser.fz-juelich.de/record/908572},
}