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@ARTICLE{deSantis:908575,
      author       = {de Santis, Augusta and Scoppola, Ernesto and Ottaviani,
                      Maria Francesca and Koutsioubas, Alexandros and Barnsley,
                      Lester C. and Paduano, Luigi and D’Errico, Gerardino and
                      Russo Krauss, Irene},
      title        = {{O}rder vs. {D}isorder: {C}holesterol and {O}mega-3
                      {P}hospholipids {D}etermine {B}iomembrane {O}rganization},
      journal      = {International journal of molecular sciences},
      volume       = {23},
      number       = {10},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {FZJ-2022-02699},
      pages        = {5322 -},
      year         = {2022},
      abstract     = {Lipid structural diversity strongly affects biomembrane
                      chemico-physical and structural properties in addition to
                      membrane-associated events. At high concentrations,
                      cholesterol increases membrane order and rigidity, while
                      polyunsaturated lipids are reported to increase disorder and
                      flexibility. How these different tendencies balance in
                      composite bilayers is still controversial. In this study,
                      electron paramagnetic resonance spectroscopy, small angle
                      neutron scattering, and neutron reflectivity were used to
                      investigate the structural properties of
                      cholesterol-containing lipid bilayers in the fluid state
                      with increasing amounts of polyunsaturated omega-3 lipids.
                      Either the hybrid
                      1-stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine or
                      the symmetric
                      1,2-docosahexaenoyl-sn-glycero-3-phosphocholine were added
                      to the mixture of the naturally abundant
                      1-palmitoyl-2-oleyl-sn-glycero-3-phosphocholine and
                      cholesterol. Our results indicate that the hybrid and the
                      symmetric omega-3 phospholipids affect the microscopic
                      organization of lipid bilayers differently. Cholesterol does
                      not segregate from polyunsaturated phospholipids and,
                      through interactions with them, is able to suppress the
                      formation of non-lamellar structures induced by the
                      symmetric polyunsaturated lipid. However, this
                      order/disorder balance leads to a bilayer whose structural
                      organization cannot be ascribed to either a liquid ordered
                      or to a canonical liquid disordered phase, in that it
                      displays a very loose packing of the intermediate segments
                      of lipid chains.},
      cin          = {JCNS-FRM-II / MLZ / JCNS-4},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 / I:(DE-588b)4597118-3 /
                      I:(DE-Juel1)JCNS-4-20201012},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (FZJ)
                      (POF4-6G4) / 632 - Materials – Quantum, Complex and
                      Functional Materials (POF4-632)},
      pid          = {G:(DE-HGF)POF4-6G4 / G:(DE-HGF)POF4-632},
      experiment   = {EXP:(DE-MLZ)KWS1-20140101 / EXP:(DE-MLZ)MARIA-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35628128},
      UT           = {WOS:000802443900001},
      doi          = {10.3390/ijms23105322},
      url          = {https://juser.fz-juelich.de/record/908575},
}