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@ARTICLE{Maity:909070,
      author       = {Maity, Debabrata and Oh, Yujeong and Gremer, Lothar and
                      Hoyer, Wolfgang and Magzoub, Mazin and Hamilton, Andrew D},
      title        = {{C}ucurbit[7]uril {I}nhibits {I}slet {A}myloid
                      {P}olypeptide {A}ggregation by {T}argeting {N} {T}erminus
                      {H}ot {S}egments and {A}ttenuates {C}ytotoxicity.},
      journal      = {Chemistry - a European journal},
      volume       = {28},
      number       = {38},
      issn         = {0947-6539},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {FZJ-2022-02988},
      pages        = {e202200456},
      year         = {2022},
      note         = {Kein Post-print vorhanden},
      abstract     = {Two 'hot segments' within an islet amyloid polypeptide are
                      responsible for its self-assembly, which in turn is linked
                      to the decline of β-cells in type 2 diabetes (T2D). A
                      readily available water-soluble, macrocyclic host,
                      cucurbit[7]uril (CB[7]), effectively inhibits islet amyloid
                      polypeptide (IAPP) aggregation through ion-dipole and
                      hydrophobic interactions with different residues of the
                      monomeric peptide in its random-coil conformation. A HSQC
                      NMR study shows that CB[7] likely modulates IAPP
                      self-assembly by interacting with and masking major residues
                      present in the 'hot segments' at the N terminus. CB[7] also
                      prevents the formation of toxic oligomers and inhibits
                      seed-catalyzed fibril proliferation. Importantly, CB[7]
                      recovers rat insulinoma cells (RIN-m) from IAPP-assembly
                      associated cytotoxicity.},
      keywords     = {Amyloid: chemistry / Animals / Diabetes Mellitus, Type 2 /
                      Heterocyclic Compounds, 2-Ring / Imidazolidines /
                      Insulin-Secreting Cells / Islet Amyloid Polypeptide:
                      chemistry / Macrocyclic Compounds / Rats / amyloid fibrils
                      (Other) / cucurbit[7]uril (Other) / islet amyloid
                      polypeptides (Other) / macrocyclic hosts (Other) / protein
                      assembly (Other) / type 2 diabetes (Other) / Amyloid (NLM
                      Chemicals) / Heterocyclic Compounds, 2-Ring (NLM Chemicals)
                      / Imidazolidines (NLM Chemicals) / Islet Amyloid Polypeptide
                      (NLM Chemicals) / Macrocyclic Compounds (NLM Chemicals) /
                      cucurbit(7)uril (NLM Chemicals)},
      cin          = {IBI-7},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35532096},
      UT           = {WOS:000803082700001},
      doi          = {10.1002/chem.202200456},
      url          = {https://juser.fz-juelich.de/record/909070},
}