Hauptseite > Publikationsdatenbank > Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity. > print

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024 7 _ |a 10.1002/chem.202200456
|2 doi
024 7 _ |a pmid:35532096
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024 7 _ |a 0947-6539
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024 7 _ |a 1521-3765
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037 _ _ |a FZJ-2022-02988
041 _ _ |a English
082 _ _ |a 540
100 1 _ |a Maity, Debabrata
|0 0000-0002-4301-3106
|b 0
|e Corresponding author
245 _ _ |a Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity.
260 _ _ |a Weinheim
|c 2022
|b Wiley-VCH
336 7 _ |a article
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500 _ _ |a Kein Post-print vorhanden
520 _ _ |a Two 'hot segments' within an islet amyloid polypeptide are responsible for its self-assembly, which in turn is linked to the decline of β-cells in type 2 diabetes (T2D). A readily available water-soluble, macrocyclic host, cucurbit[7]uril (CB[7]), effectively inhibits islet amyloid polypeptide (IAPP) aggregation through ion-dipole and hydrophobic interactions with different residues of the monomeric peptide in its random-coil conformation. A HSQC NMR study shows that CB[7] likely modulates IAPP self-assembly by interacting with and masking major residues present in the 'hot segments' at the N terminus. CB[7] also prevents the formation of toxic oligomers and inhibits seed-catalyzed fibril proliferation. Importantly, CB[7] recovers rat insulinoma cells (RIN-m) from IAPP-assembly associated cytotoxicity.
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650 _ 7 |a amyloid fibrils
|2 Other
650 _ 7 |a cucurbit[7]uril
|2 Other
650 _ 7 |a islet amyloid polypeptides
|2 Other
650 _ 7 |a macrocyclic hosts
|2 Other
650 _ 7 |a protein assembly
|2 Other
650 _ 7 |a type 2 diabetes
|2 Other
650 _ 7 |a Amyloid
|2 NLM Chemicals
650 _ 7 |a Heterocyclic Compounds, 2-Ring
|2 NLM Chemicals
650 _ 7 |a Imidazolidines
|2 NLM Chemicals
650 _ 7 |a Islet Amyloid Polypeptide
|2 NLM Chemicals
650 _ 7 |a Macrocyclic Compounds
|2 NLM Chemicals
650 _ 7 |a cucurbit(7)uril
|2 NLM Chemicals
650 _ 2 |a Amyloid: chemistry
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Diabetes Mellitus, Type 2
|2 MeSH
650 _ 2 |a Heterocyclic Compounds, 2-Ring
|2 MeSH
650 _ 2 |a Imidazolidines
|2 MeSH
650 _ 2 |a Insulin-Secreting Cells
|2 MeSH
650 _ 2 |a Islet Amyloid Polypeptide: chemistry
|2 MeSH
650 _ 2 |a Macrocyclic Compounds
|2 MeSH
650 _ 2 |a Rats
|2 MeSH
700 1 _ |a Oh, Yujeong
|0 P:(DE-HGF)0
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700 1 _ |a Gremer, Lothar
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700 1 _ |a Hoyer, Wolfgang
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700 1 _ |a Magzoub, Mazin
|0 0000-0003-3414-6617
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700 1 _ |a Hamilton, Andrew D
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773 _ _ |a 10.1002/chem.202200456
|g Vol. 28, no. 38
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|n 38
|p e202200456
|t Chemistry - a European journal
|v 28
|y 2022
|x 0947-6539
856 4 _ |u https://juser.fz-juelich.de/record/909070/files/Chemistry%20A%20European%20J%20-%202022%20-%20Maity%20-%20Cucurbit%207%20uril%20Inhibits%20Islet%20Amyloid%20Polypeptide%20Aggregation%20by%20Targeting%20N.pdf
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