000909100 001__ 909100
000909100 005__ 20230516202230.0
000909100 0247_ $$2doi$$a10.1186/s40478-022-01327-6
000909100 0247_ $$2Handle$$a2128/31673
000909100 0247_ $$2pmid$$a35209932
000909100 0247_ $$2WOS$$aWOS:000780780600001
000909100 037__ $$aFZJ-2022-03010
000909100 041__ $$aEnglish
000909100 082__ $$a610
000909100 1001_ $$0P:(DE-HGF)0$$aLohmann, Stephanie$$b0
000909100 245__ $$aIschemic stroke causes Parkinson’s disease-like pathology and symptoms in transgenic mice overexpressing alpha-synuclein
000909100 260__ $$aLondon$$bBiomed Central$$c2022
000909100 3367_ $$2DRIVER$$aarticle
000909100 3367_ $$2DataCite$$aOutput Types/Journal article
000909100 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1684231833_25722
000909100 3367_ $$2BibTeX$$aARTICLE
000909100 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000909100 3367_ $$00$$2EndNote$$aJournal Article
000909100 520__ $$aThe etiology of Parkinson's disease is poorly understood and is most commonly associated with advancing age, genetic predisposition, or environmental toxins. Epidemiological findings suggest that patients have a higher risk of developing Parkinson's disease after ischemic stroke, but this potential causality lacks mechanistic evidence. We investigated the long-term effects of ischemic stroke on pathogenesis in hemizygous TgM83 mice, which express human α-synuclein with the familial A53T mutation without developing any neuropathology or signs of neurologic disease for more than 600 days. We induced transient focal ischemia by middle cerebral artery occlusion in 2-month-old TgM83+/- mice and monitored their behavior and health status for up to 360 days post surgery. Groups of mice were sacrificed at 14, 30, 90, 180, and 360 days after surgery for neuropathological analysis of their brains. Motor deficits first appeared 6 months after focal ischemia and worsened until 12 months afterward. Immunohistochemical analysis revealed ischemia-induced neuronal loss in the infarct region and astrogliosis and microgliosis indicative of an inflammatory response, which was most pronounced at 14 days post surgery. Infarct volume and inflammation gradually decreased in size and severity until 180 days post surgery. Surprisingly, neuronal loss and inflammation were increased again by 360 days post surgery. These changes were accompanied by a continuous increase in α-synuclein aggregation, its neuronal deposition, and a late loss of dopaminergic neurons in the substantia nigra, which we detected at 360 days post surgery. Control animals that underwent sham surgery without middle cerebral artery occlusion showed no signs of disease or neuropathology. Our results establish a mechanistic link between ischemic stroke and Parkinson's disease and provide an animal model for studying possible interventions.
000909100 536__ $$0G:(DE-HGF)POF4-5244$$a5244 - Information Processing in Neuronal Networks (POF4-524)$$cPOF4-524$$fPOF IV$$x0
000909100 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
000909100 7001_ $$0P:(DE-HGF)0$$aGrigoletto, Jessica$$b1
000909100 7001_ $$0P:(DE-HGF)0$$aBernis, Maria Eugenia$$b2
000909100 7001_ $$0P:(DE-Juel1)178945$$aPesch, Verena$$b3$$ufzj
000909100 7001_ $$0P:(DE-Juel1)180536$$aMa, Liang$$b4$$ufzj
000909100 7001_ $$0P:(DE-Juel1)185633$$aReithofer, Sara$$b5$$ufzj
000909100 7001_ $$0P:(DE-Juel1)177986$$aTamgüney, Gültekin$$b6$$eCorresponding author
000909100 773__ $$0PERI:(DE-600)2715589-4$$a10.1186/s40478-022-01327-6$$gVol. 10, no. 1, p. 26$$n1$$p26$$tActa Neuropathologica Communications$$v10$$x2051-5960$$y2022
000909100 8564_ $$uhttps://juser.fz-juelich.de/record/909100/files/Invoice_6106551477.pdf
000909100 8564_ $$uhttps://juser.fz-juelich.de/record/909100/files/s40478-022-01327-6.pdf$$yOpenAccess
000909100 8767_ $$86106551477$$92022-02-22$$d2022-02-25$$eAPC$$jZahlung erfolgt$$zBelegnr. 1200177811
000909100 909CO $$ooai:juser.fz-juelich.de:909100$$pdriver$$pOpenAPC$$popen_access$$popenaire$$pdnbdelivery$$popenCost$$pVDB
000909100 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)178945$$aForschungszentrum Jülich$$b3$$kFZJ
000909100 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)180536$$aForschungszentrum Jülich$$b4$$kFZJ
000909100 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)185633$$aForschungszentrum Jülich$$b5$$kFZJ
000909100 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)177986$$aForschungszentrum Jülich$$b6$$kFZJ
000909100 9131_ $$0G:(DE-HGF)POF4-524$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5244$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vMolecular and Cellular Information Processing$$x0
000909100 9141_ $$y2022
000909100 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-01-28
000909100 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-01-28
000909100 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-01-28
000909100 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2021-01-28
000909100 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000909100 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000909100 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2021-01-28
000909100 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bACTA NEUROPATHOL COM : 2021$$d2022-11-09
000909100 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-09
000909100 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-09
000909100 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-02-14T16:20:11Z
000909100 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-02-14T16:20:11Z
000909100 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review$$d2021-02-14T16:20:11Z
000909100 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-09
000909100 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-09
000909100 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-09
000909100 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-09
000909100 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-09
000909100 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bACTA NEUROPATHOL COM : 2021$$d2022-11-09
000909100 915pc $$0PC:(DE-HGF)0000$$2APC$$aAPC keys set
000909100 915pc $$0PC:(DE-HGF)0001$$2APC$$aLocal Funding
000909100 915pc $$0PC:(DE-HGF)0002$$2APC$$aDFG OA Publikationskosten
000909100 915pc $$0PC:(DE-HGF)0003$$2APC$$aDOAJ Journal
000909100 920__ $$lyes
000909100 9201_ $$0I:(DE-Juel1)IBI-7-20200312$$kIBI-7$$lStrukturbiochemie$$x0
000909100 9801_ $$aFullTexts
000909100 980__ $$ajournal
000909100 980__ $$aVDB
000909100 980__ $$aI:(DE-Juel1)IBI-7-20200312
000909100 980__ $$aUNRESTRICTED
000909100 980__ $$aAPC