TY  - CONF
AU  - Jiang, H.-J.
AU  - Aćimović, J.
AU  - Manninen, T.
AU  - Stapmanns, J.
AU  - Lehtimäki, M.
AU  - Linne, M.-L.
AU  - Diesmann, M.
AU  - van Albada, S. J.
TI  - Modeling spiking networks with neuron-glia interactions in NEST
M1  - FZJ-2022-03029
PY  - 2022
N1  - References[1] Lines J et al. (2020) Astrocytes modulate sensory-evoked neuronal network activity. Nat Commun. 11:3689.doi:10.1038/s41467-020-17536-3.[2] Zisis E et al (2021) Digital reconstruction of the neuro-glia-vascular architecture. Cereb. Cortex, 2021;00:1-18[3] Bazargani N and Attwell D. (2016) Astrocyte calcium signaling: the third wave. Nat. Neurosci. 19(2):182-9.doi: 10.1038/nn.4201[4] Linne M-L et al. (2022) Neuron–Glia Interactions and Brain Circuits. In: Giugliano, M., Negrello, M.,Linaro, D. (eds) Computational Modelling of the Brain. Advances in Experimental Medicine and Biology, vol1359. Springer, Cham. https://doi.org/10.1007/978-3-030-89439-9_4[5] Manninen T et al. (2018) Front. Neuroinf. 12:20. doi.org/10.3389/fninf.2018.00020
AB  - Recent experimental evidence suggests an active roles of astrocytes in a number of brain functions and demon-strates coordinated neuronal and astrocytic activity in vivo [1]. In the cortex, astrocytes form non-overlappingdomains, each containing several hundreds of neurons and ~100,000 synapses [2]. Astrocytic processes arein close contact with synaptic terminals and affect synaptic transmission, plasticity, and neuronal excitability[3, 4]. Understanding the role of astrocytic mechanisms in brain functions and dysfunctions requires open-access tools for model implementation, simulation, and analysis. In the past decade, hundreds of new modelswith some form of neuron-astrocyte interaction dynamics have been proposed. However, their implementa-tion is rarely shared and not sufficiently documented to reproduce the findings [4, 5]. We developed a newmodule in the NEST simulator that allows efficient implementation and simulation of large neuron-astrocytepopulations. This includes an astrocyte model with internal calcium dynamics, a synapse model to commu-nicate between astrocytes and postsynaptic neurons, and user-friendly and efficient high-level connectivityfunctions, which allow probabilistic or deterministic pairing of neurons and astrocytes. This new module willimprove the convenience, reliability, and reproducibility of computational studies involving neuron-astrocyteinteractions.
T2  - NEST Conference 2022
CY  - 23 Jun 2022 - 24 Jun 2022, virtual (virtual)
Y2  - 23 Jun 2022 - 24 Jun 2022
M2  - virtual, virtual
LB  - PUB:(DE-HGF)24
UR  - https://juser.fz-juelich.de/record/909129
ER  -