TY  - JOUR
AU  - Ruan, Vanessa Ande
AU  - Hartz, Arne
AU  - Hueck, Manuel
AU  - Dahmen, Brigitte
AU  - von Polier, Georg
AU  - Herpertz-Dahlmann, Beate
AU  - Konrad, Kerstin
AU  - Schulte-Rüther, Martin
AU  - Seitz, Jochen
TI  - Neural mechanisms underlying Social Recognition and Theory of Mind in Adolescent Patients with Bulimia Nervosa and Transdiagnostic Comparison with Anorexia Nervosa
JO  - European eating disorders review
VL  - 30
IS  - 5
SN  - 1072-4133
CY  - Chichester
PB  - Wiley
M1  - FZJ-2022-03038
SP  - 486-500
PY  - 2022
AB  - IntroductionTheory of mind (ToM) is important for social interactions and typical development and has been found to be impaired in patients with anorexia nervosa (AN) and bulimia nervosa (BN). Hypoactivation in frontotemporal brain regions seems to be the underlying neural mechanism in AN while whole-brain analyses in BN are lacking.MethodsWe used the well-validated social recognition task fMRI paradigm to assess ToM in a total of 72 female adolescents (16 BN, 18 AN and 38 matched healthy controls [HC]).ResultsCompared to HCBN, patients with BN showed hyperactivity during ToM-activity in the right frontal pole, middle temporal gyrus and left temporal pole and differed fundamentally from hypoactivation in these regions observed in patients with AN before and after short-term weight rehabilitation. Interaction and overlap analyses confirmed that similar regions were affected in opposite directions in both diseases. Hyperactivations in BN in the right middle temporal gyrus and right frontal pole were associated with clinical BN-severity markers binging and purging frequency.DiscussionThe hyperactivation in BN suggest different underlying neural mechanisms for ToM compared to AN. Hyperactivity might correspond to a different but also ineffective cognitive style in patients with BN when approaching social interactions. These important transdiagnostic differences are relevant for future brain-targeted therapeutic approaches.
LB  - PUB:(DE-HGF)16
C6  - 35701077
UR  - <Go to ISI:>//WOS:000810701700001
DO  - DOI:10.1002/erv.2911
UR  - https://juser.fz-juelich.de/record/909159
ER  -