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@ARTICLE{Ruan:909159,
      author       = {Ruan, Vanessa Ande and Hartz, Arne and Hueck, Manuel and
                      Dahmen, Brigitte and von Polier, Georg and
                      Herpertz-Dahlmann, Beate and Konrad, Kerstin and
                      Schulte-Rüther, Martin and Seitz, Jochen},
      title        = {{N}eural mechanisms underlying {S}ocial {R}ecognition and
                      {T}heory of {M}ind in {A}dolescent {P}atients with {B}ulimia
                      {N}ervosa and {T}ransdiagnostic {C}omparison with {A}norexia
                      {N}ervosa},
      journal      = {European eating disorders review},
      volume       = {30},
      number       = {5},
      issn         = {1072-4133},
      address      = {Chichester},
      publisher    = {Wiley},
      reportid     = {FZJ-2022-03038},
      pages        = {486-500},
      year         = {2022},
      abstract     = {IntroductionTheory of mind (ToM) is important for social
                      interactions and typical development and has been found to
                      be impaired in patients with anorexia nervosa (AN) and
                      bulimia nervosa (BN). Hypoactivation in frontotemporal brain
                      regions seems to be the underlying neural mechanism in AN
                      while whole-brain analyses in BN are lacking.MethodsWe used
                      the well-validated social recognition task fMRI paradigm to
                      assess ToM in a total of 72 female adolescents (16 BN, 18 AN
                      and 38 matched healthy controls [HC]).ResultsCompared to
                      HCBN, patients with BN showed hyperactivity during
                      ToM-activity in the right frontal pole, middle temporal
                      gyrus and left temporal pole and differed fundamentally from
                      hypoactivation in these regions observed in patients with AN
                      before and after short-term weight rehabilitation.
                      Interaction and overlap analyses confirmed that similar
                      regions were affected in opposite directions in both
                      diseases. Hyperactivations in BN in the right middle
                      temporal gyrus and right frontal pole were associated with
                      clinical BN-severity markers binging and purging
                      frequency.DiscussionThe hyperactivation in BN suggest
                      different underlying neural mechanisms for ToM compared to
                      AN. Hyperactivity might correspond to a different but also
                      ineffective cognitive style in patients with BN when
                      approaching social interactions. These important
                      transdiagnostic differences are relevant for future
                      brain-targeted therapeutic approaches.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35701077},
      UT           = {WOS:000810701700001},
      doi          = {10.1002/erv.2911},
      url          = {https://juser.fz-juelich.de/record/909159},
}