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000909180 1001_ $$0P:(DE-HGF)0$$aSakreida, Katrin$$b0$$eCorresponding author
000909180 245__ $$aDisentangling dyskinesia from parkinsonism in motor structures of patients with schizophrenia
000909180 260__ $$a[Großbritannien]$$bGuarantors of Brain$$c2022
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000909180 520__ $$aPatients with schizophrenia frequently suffer from motor abnormalities, but underlying alterations in neuroarchitecture remain unclear. Here, we aimed to disentangle dyskinesia from parkinsonism in motor structures of patients with schizophrenia and to assess associated molecular architecture. We measured grey matter of motor regions and correlated volumetric estimates with dyskinesia and parkinsonism severity. Associations with molecular architecture were identified by cross-modal spatial correlations between ensuing maps of abnormality-related volume alterations and neurotransmitter maps from healthy populations. Both phenomena were linked to (specific) striatal and basal forebrain reductions as well as to D1 receptor density. Dyskinesia also manifested in cerebellar decrease, while parkinsonism was associated with less motor cortex volume. The parkinsonism-related brain pattern was additionally associated with 5-HT1A/2A and µ-opioid receptors distribution. Findings suggest the need to develop psychopharmacological compounds that display not only selectivity for receptor subtypes but also anatomical selectivity for alleviating dyskinesia without worsening parkinsonism and vice versa.
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000909180 7001_ $$0P:(DE-HGF)0$$aChiu, Wei-Hua$$b1
000909180 7001_ $$0P:(DE-Juel1)177727$$aDukart, Jürgen$$b2
000909180 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B$$b3
000909180 7001_ $$0P:(DE-HGF)0$$aFrodl, Thomas$$b4
000909180 7001_ $$0P:(DE-HGF)0$$aGaser, Christian$$b5
000909180 7001_ $$0P:(DE-HGF)0$$aLandgrebe, Michael$$b6
000909180 7001_ $$0P:(DE-HGF)0$$aLangguth, Berthold$$b7
000909180 7001_ $$0P:(DE-HGF)0$$aMirlach, Daniela$$b8
000909180 7001_ $$0P:(DE-HGF)0$$aRautu, Ioana-Sabina$$b9
000909180 7001_ $$0P:(DE-HGF)0$$aWittmann, Markus$$b10
000909180 7001_ $$0P:(DE-HGF)0$$aPoeppl, Timm B$$b11
000909180 773__ $$0PERI:(DE-600)3020013-1$$a10.1093/braincomms/fcac190$$gVol. 4, no. 4, p. fcac190$$n4$$pfcac190$$tBrain communications$$v4$$x2632-1297$$y2022
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000909180 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Grossman School of Medicine, New York University$$b1
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000909180 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)177727$$a HHU Düsseldorf$$b2
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000909180 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Department of Neurology, Jena University$$b5
000909180 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Department of Psychiatry, Psychotherapy and Psychosomatics, kbo-Lech-Mangfall-Klinik Agatharied , Hausham$$b6
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000909180 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Université Libre de Bruxelles$$b9
000909180 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a District Hospital Wöllershof, Störnstein$$b10
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