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@ARTICLE{Sakreida:909180,
      author       = {Sakreida, Katrin and Chiu, Wei-Hua and Dukart, Jürgen and
                      Eickhoff, Simon B and Frodl, Thomas and Gaser, Christian and
                      Landgrebe, Michael and Langguth, Berthold and Mirlach,
                      Daniela and Rautu, Ioana-Sabina and Wittmann, Markus and
                      Poeppl, Timm B},
      title        = {{D}isentangling dyskinesia from parkinsonism in motor
                      structures of patients with schizophrenia},
      journal      = {Brain communications},
      volume       = {4},
      number       = {4},
      issn         = {2632-1297},
      address      = {[Großbritannien]},
      publisher    = {Guarantors of Brain},
      reportid     = {FZJ-2022-03051},
      pages        = {fcac190},
      year         = {2022},
      abstract     = {Patients with schizophrenia frequently suffer from motor
                      abnormalities, but underlying alterations in
                      neuroarchitecture remain unclear. Here, we aimed to
                      disentangle dyskinesia from parkinsonism in motor structures
                      of patients with schizophrenia and to assess associated
                      molecular architecture. We measured grey matter of motor
                      regions and correlated volumetric estimates with dyskinesia
                      and parkinsonism severity. Associations with molecular
                      architecture were identified by cross-modal spatial
                      correlations between ensuing maps of abnormality-related
                      volume alterations and neurotransmitter maps from healthy
                      populations. Both phenomena were linked to (specific)
                      striatal and basal forebrain reductions as well as to D1
                      receptor density. Dyskinesia also manifested in cerebellar
                      decrease, while parkinsonism was associated with less motor
                      cortex volume. The parkinsonism-related brain pattern was
                      additionally associated with 5-HT1A/2A and µ-opioid
                      receptors distribution. Findings suggest the need to develop
                      psychopharmacological compounds that display not only
                      selectivity for receptor subtypes but also anatomical
                      selectivity for alleviating dyskinesia without worsening
                      parkinsonism and vice versa.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35912135},
      UT           = {WOS:000835001700001},
      doi          = {10.1093/braincomms/fcac190},
      url          = {https://juser.fz-juelich.de/record/909180},
}