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000909232 1001_ $$0P:(DE-HGF)0$$aDevan, Senthil-Kumar$$b0
000909232 245__ $$aA MademoiseLLE domain binding platform links the key RNA transporter to endosomes
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000909232 520__ $$aSpatiotemporal expression can be achieved by transport and translation of mRNAs at defined subcellular sites. An emerging mechanism mediating mRNA trafficking is microtubule-dependent co-transport on shuttling endosomes. Although progress has been made in identifying various components of the endosomal mRNA transport machinery, a mechanistic understanding of how these RNA-binding proteins are connected to endosomes is still lacking. Here, we demonstrate that a flexible MademoiseLLE (MLLE) domain platform within RNA-binding protein Rrm4 of Ustilago maydis is crucial for endosomal attachment. Our structure/function analysis uncovered three MLLE domains at the C-terminus of Rrm4 with a functionally defined hierarchy. MLLE3 recognises two PAM2-like sequences of the adaptor protein Upa1 and is essential for endosomal shuttling of Rrm4. MLLE1 and MLLE2 are most likely accessory domains exhibiting a variable binding mode for interaction with currently unknown partners. Thus, endosomal attachment of the mRNA transporter is orchestrated by a sophisticated MLLE domain binding platform.
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000909232 7001_ $$0P:(DE-Juel1)187014$$aSchott-Verdugo, Stephan$$b1
000909232 7001_ $$0P:(DE-HGF)0$$aMüntjes, Kira$$b2
000909232 7001_ $$0P:(DE-HGF)0$$aBismar, Lilli$$b3
000909232 7001_ $$00000-0001-5969-4471$$aReiners, Jens$$b4
000909232 7001_ $$00000-0001-5810-170X$$aHachani, Eymen$$b5
000909232 7001_ $$00000-0002-1167-9819$$aSchmitt, Lutz$$b6
000909232 7001_ $$0P:(DE-HGF)0$$aHöppner, Astrid$$b7
000909232 7001_ $$00000-0003-0780-9251$$aSmits, Sander HJ$$b8$$eCorresponding author
000909232 7001_ $$0P:(DE-Juel1)172663$$aGohlke, Holger$$b9$$eCorresponding author$$ufzj
000909232 7001_ $$00000-0003-0046-983X$$aFeldbrügge, Michael$$b10$$eCorresponding author
000909232 773__ $$0PERI:(DE-600)2186725-2$$a10.1371/journal.pgen.1010269$$gVol. 18, no. 6, p. e1010269 -$$n6$$pe1010269 -$$tPLoS Genetics$$v18$$x1553-7390$$y2022
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