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| 001 | 909232 | ||
| 005 | 20230128125811.0 | ||
| 024 | 7 | _ | |a 10.1371/journal.pgen.1010269 |2 doi |
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| 100 | 1 | _ | |a Devan, Senthil-Kumar |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a A MademoiseLLE domain binding platform links the key RNA transporter to endosomes |
| 260 | _ | _ | |a San Francisco, Calif. |c 2022 |b Public Library of Science |
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| 520 | _ | _ | |a Spatiotemporal expression can be achieved by transport and translation of mRNAs at defined subcellular sites. An emerging mechanism mediating mRNA trafficking is microtubule-dependent co-transport on shuttling endosomes. Although progress has been made in identifying various components of the endosomal mRNA transport machinery, a mechanistic understanding of how these RNA-binding proteins are connected to endosomes is still lacking. Here, we demonstrate that a flexible MademoiseLLE (MLLE) domain platform within RNA-binding protein Rrm4 of Ustilago maydis is crucial for endosomal attachment. Our structure/function analysis uncovered three MLLE domains at the C-terminus of Rrm4 with a functionally defined hierarchy. MLLE3 recognises two PAM2-like sequences of the adaptor protein Upa1 and is essential for endosomal shuttling of Rrm4. MLLE1 and MLLE2 are most likely accessory domains exhibiting a variable binding mode for interaction with currently unknown partners. Thus, endosomal attachment of the mRNA transporter is orchestrated by a sophisticated MLLE domain binding platform. |
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| 700 | 1 | _ | |a Schott-Verdugo, Stephan |0 P:(DE-Juel1)187014 |b 1 |
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| 700 | 1 | _ | |a Schmitt, Lutz |0 0000-0002-1167-9819 |b 6 |
| 700 | 1 | _ | |a Höppner, Astrid |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Smits, Sander HJ |0 0000-0003-0780-9251 |b 8 |e Corresponding author |
| 700 | 1 | _ | |a Gohlke, Holger |0 P:(DE-Juel1)172663 |b 9 |e Corresponding author |u fzj |
| 700 | 1 | _ | |a Feldbrügge, Michael |0 0000-0003-0046-983X |b 10 |e Corresponding author |
| 773 | _ | _ | |a 10.1371/journal.pgen.1010269 |g Vol. 18, no. 6, p. e1010269 - |0 PERI:(DE-600)2186725-2 |n 6 |p e1010269 - |t PLoS Genetics |v 18 |y 2022 |x 1553-7390 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/909232/files/journal.pgen.1010269.pdf |y OpenAccess |
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