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@ARTICLE{Schiel:909233,
      author       = {Schiel, Julian E. and Tamm, Sandra and Holub, Florian and
                      Petri, Roxana and Dashti, Hassan S. and Domschke, Katharina
                      and Feige, Bernd and Lane, Jacqueline M. and Riemann, Dieter
                      and Rutter, Martin K. and Saxena, Richa and Tahmasian,
                      Masoud and Wang, Heming and Kyle, Simon D. and
                      Spiegelhalder, Kai},
      title        = {{A}ssociations {B}etween {S}leep {H}ealth and {A}mygdala
                      {R}eactivity to {N}egative {F}acial {E}xpressions in the
                      {UK} {B}iobank {C}ohort},
      journal      = {Biological psychiatry},
      volume       = {.},
      issn         = {0006-3223},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2022-03077},
      pages        = {S0006322322012835},
      year         = {2022},
      abstract     = {Background: Sleep health (SH) is considered a key
                      determinant of human physiological and psychological
                      well-being. In line with this, previous studies have found
                      that poor sleep is associated with various psychiatric
                      disorders, in particular, with anxiety and depression.
                      Although little is known about the neural mechanisms
                      underlying these associations, recent findings suggest that
                      essential dimensions of SH are associated with altered
                      amygdala reactivity (AR); however, evidence to date is
                      inconsistent and reliant on small sample sizes.Methods: To
                      address this problem, the current preregistered study
                      investigated associations between SH and AR to negative
                      facial expressions in the UK Biobank cohort (25,758
                      participants). Drawing on a large sample size and consistent
                      data acquisition, 5 dimensions of SH (insomnia symptoms,
                      sleep duration, daytime sleepiness, chronotype, and sleep
                      medication) were examined.Results: Exploratory analyses
                      revealed that short sleep duration was associated with
                      decreased AR. The remaining SH dimensions and a composite
                      measure of all SH dimensions were not associated with
                      AR.Conclusions: To our knowledge, this is the largest study
                      to test associations between SH and AR. Habitual short sleep
                      duration may be associated with decreased AR, possibly
                      indicating compensation for impaired prefrontal processes
                      and hampered emotion regulation.Keywords: Amygdala
                      reactivity; Emotion regulation; Emotional reactivity; Sleep
                      duration; Sleep health; UK Biobank.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35933167},
      UT           = {WOS:000878185900004},
      doi          = {10.1016/j.biopsych.2022.05.023},
      url          = {https://juser.fz-juelich.de/record/909233},
}