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@ARTICLE{Feng:909364,
      author       = {Feng, Chunliang and Huang, Wenhao and Xu, Kangli and
                      Stewart, Jennifer L. and Camilleri, Julia and Yang, Xiaofeng
                      and Wei, Ping and Gu, Ruolei and Luo, Wenbo and Eickhoff,
                      Simon},
      title        = {{N}eural substrates of motivational dysfunction across
                      neuropsychiatric conditions: {E}vidence from meta-analysis
                      and lesion network mapping},
      journal      = {Clinical psychology review},
      volume       = {96},
      issn         = {0272-7358},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2022-03154},
      pages        = {102189 -},
      year         = {2022},
      abstract     = {Motivational dysfunction constitutes one of the fundamental
                      dimensions of psychopathology cutting across traditional
                      diagnostic boundaries. However, it is unclear whether there
                      is a common neural circuit responsible for motivational
                      dysfunction across neuropsychiatric conditions. To address
                      this issue, the current study combined a meta-analysis on
                      psychiatric neuroimaging studies of reward/loss anticipation
                      and consumption (4308 foci, 438 contrasts, 129 publications)
                      with a lesion network mapping approach (105 lesion cases).
                      Our meta-analysis identified transdiagnostic hypoactivation
                      in the ventral striatum (VS) for clinical/at-risk conditions
                      compared to controls during the anticipation of both reward
                      and loss. Moreover, the VS subserves a key node in a
                      distributed brain network which encompasses heterogeneous
                      lesion locations causing motivation-related symptoms. These
                      findings do not only provide the first meta-analytic
                      evidence of shared neural alternations linked to
                      anticipatory motivation-related deficits, but also shed
                      novel light on the role of VS dysfunction in motivational
                      impairments in terms of both network integration and
                      psychological functions. Particularly, the current findings
                      suggest that motivational dysfunction across
                      neuropsychiatric conditions is rooted in disruptions of a
                      common brain network anchored in the VS, which contributes
                      to motivational salience processing rather than encoding
                      positive incentive values.},
      cin          = {INM-7},
      ddc          = {150},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35908312},
      UT           = {WOS:000841261000002},
      doi          = {10.1016/j.cpr.2022.102189},
      url          = {https://juser.fz-juelich.de/record/909364},
}