TY  - JOUR
AU  - Doppler, Christopher
AU  - Meyer, Linda
AU  - Seger, Aline
AU  - Karges, Wolfram
AU  - Weiss-Blankenhorn, Peter
AU  - Fink, Gereon R.
TI  - Intranasal oxytocin attenuates the effects of monetary feedback on procedural learning
JO  - Psychoneuroendocrinology
VL  - 143
SN  - 0306-4530
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2022-03206
SP  - 105823 -
PY  - 2022
AB  - Procedural learning is a vital brain function that allows us to acquire motor skills during development or re-learnthem after lesions affecting the motor system. Procedural learning can be improved by feedback of differentvalence, e.g., monetary or social, mediated by dopaminergic circuits. While processing motivationally relevantstimuli, dopamine interacts closely with oxytocin, whose effects on procedural learning, particularly feedbackbasedapproaches, remain poorly understood. In a randomized, double-blind, placebo-controlled trial, weinvestigated whether oxytocin modulates the differential effects of monetary and social feedback on procedurallearning. Sixty-one healthy male participants were randomized to receive a placebo or oxytocin intranasally. Theparticipants then performed a modified serial reaction time task. Oxytocin plasma concentrations were measuredbefore and after applying the placebo or verum. Groups did not differ regarding general reaction times ormeasures of procedural learning. For the placebo group, monetary feedback improved procedural learningcompared to a neutral control condition. In contrast, the oxytocin group did not show a differential effect ofmonetary or social feedback despite a significant increase in oxytocin plasma levels after intranasal application.The data suggest that oxytocin does not influence procedural learning per se. Instead, oxytocin seems toattenuate the effects of monetary feedback on procedural learning specifically.
LB  - PUB:(DE-HGF)16
C6  - 35689985
UR  - <Go to ISI:>//WOS:000818446900011
DO  - DOI:10.1016/j.psyneuen.2022.105823
UR  - https://juser.fz-juelich.de/record/909500
ER  -