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@ARTICLE{Stumme:909572,
      author       = {Stumme, Johanna and Krämer, Camilla and Miller, Tatiana
                      and Schreiber, Jan and Caspers, Svenja and Jockwitz,
                      Christiane},
      title        = {{I}nterrelating differences in structural and functional
                      connectivity in the older adult's brain},
      journal      = {Human brain mapping},
      volume       = {43},
      number       = {18},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2022-03254},
      pages        = {5543-5561},
      year         = {2022},
      abstract     = {In the normal aging process, the functional connectome
                      restructures and shows a shift from more segregated to more
                      integrated brain networks, which manifests itself in highly
                      different cognitive performances in older adults.
                      Underpinnings of this reorganization are not fully
                      understood, but may be related to age-related differences in
                      structural connectivity, the underlying scaffold for
                      information exchange between regions. The
                      structure–function relationship might be a promising
                      factor to understand the neurobiological sources of
                      interindividual cognitive variability, but remain unclear in
                      older adults. Here, we used diffusion weighted and
                      resting-state functional magnetic resonance imaging as well
                      as cognitive performance data of 573 older subjects from the
                      1000BRAINS cohort (55–85 years, 287 males) and performed
                      a partial least square regression on 400 regional functional
                      and structural connectivity (FC and SC, respectively)
                      estimates comprising seven resting-state networks. Our aim
                      was to identify FC and SC patterns that are, together with
                      cognitive performance, characteristic of the older adults
                      aging process. Results revealed three different aging
                      profiles prevalent in older adults. FC was found to behave
                      differently depending on the severity of age-related SC
                      deteriorations. A functionally highly interconnected system
                      is associated with a structural connectome that shows only
                      minor age-related decreases. Because this connectivity
                      profile was associated with the most severe age-related
                      cognitive decline, a more interconnected FC system in older
                      adults points to a process of dedifferentiation. Thus,
                      functional network integration appears to increase primarily
                      when SC begins to decline, but this does not appear to
                      mitigate the decline in cognitive performance.},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / HBP SGA3 - Human Brain Project Specific Grant
                      Agreement 3 (945539)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(EU-Grant)945539},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35916531},
      UT           = {WOS:000834876600001},
      doi          = {10.1002/hbm.26030},
      url          = {https://juser.fz-juelich.de/record/909572},
}