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000909606 1001_ $$0P:(DE-HGF)0$$aHorsager, Jacob$$b0$$eCorresponding author
000909606 245__ $$aClinical and imaging evidence of brain-first and body-first Parkinson's disease
000909606 260__ $$aOrlando, Fla.$$bAcademic Press$$c2022
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000909606 520__ $$aBraak's hypothesis has been extremely influential over the last two decades. However, neuropathological and clinical evidence suggest that the model does not conform to all patients with Parkinson's disease (PD). To resolve this controversy, a new model was recently proposed; in brain-first PD, the initial α-synuclein pathology arise inside the central nervous system, likely rostral to the substantia nigra pars compacta, and spread via interconnected structures – eventually affecting the autonomic nervous system; in body-first PD, the initial pathological α-synuclein originates in the enteric nervous system with subsequent caudo-rostral propagation to the autonomic and central nervous system.
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000909606 7001_ $$0P:(DE-HGF)0$$aKnudsen, Karoline$$b1
000909606 7001_ $$0P:(DE-Juel1)179044$$aSommerauer, Michael$$b2$$ufzj
000909606 773__ $$0PERI:(DE-600)1471408-5$$a10.1016/j.nbd.2022.105626$$gVol. 164, p. 105626 -$$p105626 -$$tNeurobiology of disease$$v164$$x0969-9961$$y2022
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