TY  - JOUR
AU  - Horsager, Jacob
AU  - Knudsen, Karoline
AU  - Sommerauer, Michael
TI  - Clinical and imaging evidence of brain-first and body-first Parkinson's disease
JO  - Neurobiology of disease
VL  - 164
SN  - 0969-9961
CY  - Orlando, Fla.
PB  - Academic Press
M1  - FZJ-2022-03278
SP  - 105626 -
PY  - 2022
AB  - Braak's hypothesis has been extremely influential over the last two decades. However, neuropathological and clinical evidence suggest that the model does not conform to all patients with Parkinson's disease (PD). To resolve this controversy, a new model was recently proposed; in brain-first PD, the initial α-synuclein pathology arise inside the central nervous system, likely rostral to the substantia nigra pars compacta, and spread via interconnected structures – eventually affecting the autonomic nervous system; in body-first PD, the initial pathological α-synuclein originates in the enteric nervous system with subsequent caudo-rostral propagation to the autonomic and central nervous system.
LB  - PUB:(DE-HGF)16
C6  - 35031485
UR  - <Go to ISI:>//WOS:000782610700004
DO  - DOI:10.1016/j.nbd.2022.105626
UR  - https://juser.fz-juelich.de/record/909606
ER  -