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@ARTICLE{Horsager:909606,
      author       = {Horsager, Jacob and Knudsen, Karoline and Sommerauer,
                      Michael},
      title        = {{C}linical and imaging evidence of brain-first and
                      body-first {P}arkinson's disease},
      journal      = {Neurobiology of disease},
      volume       = {164},
      issn         = {0969-9961},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {FZJ-2022-03278},
      pages        = {105626 -},
      year         = {2022},
      abstract     = {Braak's hypothesis has been extremely influential over the
                      last two decades. However, neuropathological and clinical
                      evidence suggest that the model does not conform to all
                      patients with Parkinson's disease (PD). To resolve this
                      controversy, a new model was recently proposed; in
                      brain-first PD, the initial α-synuclein pathology arise
                      inside the central nervous system, likely rostral to the
                      substantia nigra pars compacta, and spread via
                      interconnected structures – eventually affecting the
                      autonomic nervous system; in body-first PD, the initial
                      pathological α-synuclein originates in the enteric nervous
                      system with subsequent caudo-rostral propagation to the
                      autonomic and central nervous system.},
      cin          = {INM-3},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35031485},
      UT           = {WOS:000782610700004},
      doi          = {10.1016/j.nbd.2022.105626},
      url          = {https://juser.fz-juelich.de/record/909606},
}