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@ARTICLE{Jergas:909608,
      author       = {Jergas, Hannah and Petry-Schmelzer, Jan Niklas and Dembek,
                      Till A. and Dafsari, Haidar S. and Visser-Vandewalle, Veerle
                      and Fink, Gereon R. and Baldermann, Juan Carlos and Barbe,
                      Michael T.},
      title        = {{B}rain {M}orphometry {A}ssociated {W}ith {R}esponse to
                      {L}evodopa and {D}eep {B}rain {S}timulation in {P}arkinson
                      {D}isease},
      journal      = {Neuromodulation},
      volume       = {26},
      number       = {2},
      issn         = {1094-7159},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {FZJ-2022-03280},
      pages        = {340-347},
      year         = {2023},
      abstract     = {ObjectivesWhether treatment response in patients with
                      Parkinson disease depends on brain atrophy is insufficiently
                      understood. The goal of this study is to identify specific
                      atrophy patterns associated with response to dopaminergic
                      therapy and deep brain stimulation.Materials and MethodsIn
                      this study, we analyzed the association of gray matter brain
                      atrophy patterns, as identified by voxel-based morphometry,
                      with acute response to levodopa (N = 118) and subthalamic
                      nucleus deep brain stimulation (N = 39). Motor status was
                      measured as a change in points on the Unified Parkinson’s
                      Disease Rating Scale III score. Baseline values were
                      obtained before surgery, after cessation of dopaminergic
                      medication for at least 12 hours; response to medication was
                      assessed after administration of a standardized dose of
                      levodopa. Response to deep brain stimulation was measured
                      three months after surgery in the clinical condition after
                      withdrawal of dopaminergic medication.ResultsAlthough
                      frontoparietal brain gray matter loss was associated with
                      subpar response to deep brain stimulation, there was no
                      significant link between brain atrophy and response to
                      levodopa.ConclusionWe conclude that response to deep brain
                      stimulation relies on gray matter integrity; hence, gray
                      matter loss may present a risk factor for poor response to
                      deep brain stimulation and may be considered when making
                      decision regarding clinical practice.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35219570},
      UT           = {WOS:000932773400001},
      doi          = {10.1016/j.neurom.2022.01.013},
      url          = {https://juser.fz-juelich.de/record/909608},
}