TY  - JOUR
AU  - Wieters, Frederique
AU  - Gruhn, Matthias
AU  - Büschges, Ansgar
AU  - Fink, Gereon R.
AU  - Aswendt, Markus
TI  - Terminal H-reflex Measurements in Mice
JO  - JoVE science education
VL  - .
IS  - 184
SN  - 1940-087X
CY  - Cambridge, MA
PB  - JoVE
M1  - FZJ-2022-03306
SP  - 63304
PY  - 2022
AB  - The Hoffmann reflex (H-reflex), as an electrical analog to the stretch reflex, allowselectrophysiological validation of the integrity of neural circuits after injuries such asspinal cord damage or stroke. An increase of the H-reflex response, together withsymptoms like non-voluntary muscle contractions, pathologically augmented stretchreflex, and hypertonia in the corresponding muscle, is an indicator of post-strokespasticity (PSS).In contrast to rather nerve-unspecific transcutaneous measurements, here, we presenta protocol to quantify the H-reflex directly at the ulnar and median nerves of theforepaw, which is applicable, with minor modifications, to the tibial and sciatic nerveof the hindpaw. Based on the direct stimulation and the adaptation to different nerves,the method represents a reliable and versatile tool to validate electrophysiologicalchanges in spasticity-related disease models.
LB  - PUB:(DE-HGF)16
C6  - 35781283
UR  - <Go to ISI:>//WOS:000898056900010
DO  - DOI:10.3791/63304
UR  - https://juser.fz-juelich.de/record/909635
ER  -