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@ARTICLE{Wieters:909635,
      author       = {Wieters, Frederique and Gruhn, Matthias and Büschges,
                      Ansgar and Fink, Gereon R. and Aswendt, Markus},
      title        = {{T}erminal {H}-reflex {M}easurements in {M}ice},
      journal      = {JoVE science education},
      volume       = {.},
      number       = {184},
      issn         = {1940-087X},
      address      = {Cambridge, MA},
      publisher    = {JoVE},
      reportid     = {FZJ-2022-03306},
      pages        = {63304},
      year         = {2022},
      abstract     = {The Hoffmann reflex (H-reflex), as an electrical analog to
                      the stretch reflex, allowselectrophysiological validation of
                      the integrity of neural circuits after injuries such
                      asspinal cord damage or stroke. An increase of the H-reflex
                      response, together withsymptoms like non-voluntary muscle
                      contractions, pathologically augmented stretchreflex, and
                      hypertonia in the corresponding muscle, is an indicator of
                      post-strokespasticity (PSS).In contrast to rather
                      nerve-unspecific transcutaneous measurements, here, we
                      presenta protocol to quantify the H-reflex directly at the
                      ulnar and median nerves of theforepaw, which is applicable,
                      with minor modifications, to the tibial and sciatic nerveof
                      the hindpaw. Based on the direct stimulation and the
                      adaptation to different nerves,the method represents a
                      reliable and versatile tool to validate
                      electrophysiologicalchanges in spasticity-related disease
                      models.},
      cin          = {INM-3},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35781283},
      UT           = {WOS:000898056900010},
      doi          = {10.3791/63304},
      url          = {https://juser.fz-juelich.de/record/909635},
}