% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Jane:909774,
      author       = {Janeš, Josip Augustin and Monzel, Cornelia and Schmidt,
                      Daniel and Merkel, Rudolf and Seifert, Udo and Sengupta,
                      Kheya and Smith, Ana-Sunčana},
      title        = {{F}irst-{P}rinciple {C}oarse-{G}raining {F}ramework for
                      {S}cale-{F}ree {B}ell-{L}ike {A}ssociation and
                      {D}issociation {R}ates in {T}hermal and {A}ctive {S}ystems},
      journal      = {Physical review / X},
      volume       = {12},
      number       = {3},
      issn         = {2160-3308},
      address      = {College Park, Md.},
      publisher    = {APS},
      reportid     = {FZJ-2022-03404},
      pages        = {031030},
      year         = {2022},
      abstract     = {Fluctuations of surfaces that harbor reactive molecules
                      interacting across the intervening space strongly influence
                      the reaction kinetics. One such paradigmatic system is the
                      cell membrane, with associated proteins, binding to an
                      interior or an exterior scaffold—for example, the
                      cytoskeleton in the former and the extracellular matrix in
                      the latter case. Given that membrane fluctuations are
                      significant and regulated by the activity of the cell, we
                      hypothesize that these active fluctuations can be tuned to
                      influence ligand-receptor-mediated adhesion. However, a
                      comprehensive model, deriving both binding and unbinding
                      rates from first principles, has not yet been established,
                      and as such, the effect of the membrane activity on the
                      rates remains an open problem. Here, we solve this issue by
                      establishing a systematic coarse graining procedure,
                      providing a cascade of expressions for rates appropriate for
                      the observed timescale, and present a scale-free formulation
                      of rates. In the first step, we introduce a minimal model to
                      recover the so-called Bell-Dembo rates from first
                      principles, where the binding and unbinding rates depend on
                      the instantaneous position of the membrane. We then derive
                      the analytical coarse-grained rates for thermal
                      fluctuations, recovering a result that has previously been
                      successfully used in the literature. Finally, we expand this
                      framework to account for active fluctuations of the
                      membrane. In this step, we develop a mechanical model that
                      convolutes Gauss and Laplace distributed noise. This choice
                      may have universal features and is motivated by our analysis
                      of measurements in two very different cell types, namely,
                      human macrophages and red blood cells. We find that cell
                      activation enables the formation of bonds at much larger
                      separations between the cell and the target. This effect is
                      significantly greater for binding to a surface on the
                      extracellular compared to the intracellular side. We thus
                      show that active fluctuations directly influence protein
                      association and dissociation rates, which may have clear
                      physiological implications that are yet to be explored.},
      cin          = {IBI-2},
      ddc          = {530},
      cid          = {I:(DE-Juel1)IBI-2-20200312},
      pnm          = {5243 - Information Processing in Distributed Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5243},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000859853800001},
      doi          = {10.1103/PhysRevX.12.031030},
      url          = {https://juser.fz-juelich.de/record/909774},
}