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@ARTICLE{Schmitt:909775,
      author       = {Schmitt, Laura Maria and Dreissen, Georg and Kolasinac,
                      Rejhana and Csiszar, Agnes and Merkel, Rudolf},
      title        = {{M}embrane tension controls the phase equilibrium in
                      fusogenic liposomes},
      journal      = {RSC Advances},
      volume       = {12},
      number       = {37},
      issn         = {2046-2069},
      address      = {London},
      publisher    = {RSC Publishing},
      reportid     = {FZJ-2022-03405},
      pages        = {24114 - 24129},
      year         = {2022},
      abstract     = {Fusogenic liposomes have been widely used for molecule
                      delivery to cell membranes and cell interior. However, their
                      physicochemical state is still little understood. We tested
                      mechanical material behavior by micropipette aspiration of
                      giant vesicles from fusogenic lipid mixtures and found that
                      the membranes of these vesicles are fluid and under high
                      mechanical tension even before aspiration. Based on this
                      result, we developed a theoretical framework to determine
                      the area expansion modulus and membrane tension of such
                      pre-tensed vesicles from aspiration experiments.
                      Surprisingly high membrane tension of 2.1 mN m−1 and very
                      low area expansion modulus of 63 mN m−1 were found. We
                      interpret these peculiar material properties as the result
                      of a mechanically driven phase transition between the usual
                      lamellar phase and an, as of now, not finally determined
                      three dimensional phase of the lipid mixture. The free
                      enthalpy of transition between these phases is very low,
                      i.e. on the order of the thermal energy.},
      cin          = {IBI-2},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBI-2-20200312},
      pnm          = {5243 - Information Processing in Distributed Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5243},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36093247},
      UT           = {WOS:000843638400001},
      doi          = {10.1039/D2RA04019K},
      url          = {https://juser.fz-juelich.de/record/909775},
}