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@ARTICLE{SriRanjan:909777,
      author       = {Sri-Ranjan, K. and Sanchez-Alonso, J. L. and Swiatlowska,
                      P. and Rothery, S. and Novak, P. and Gerlach, S. and
                      Koeninger, D. and Hoffmann, Bernd and Merkel, R. and
                      Stevens, M. M. and Sun, S. X. and Gorelik, J. and Braga,
                      Vania M. M.},
      title        = {{I}ntrinsic cell rheology drives junction maturation},
      journal      = {Nature Communications},
      volume       = {13},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {FZJ-2022-03407},
      pages        = {4832},
      year         = {2022},
      abstract     = {A fundamental property of higher eukaryotes that underpins
                      their evolutionary success is stable cell-cell cohesion.
                      Yet, how intrinsic cell rheology and stiffness contributes
                      to junction stabilization and maturation is poorly
                      understood. We demonstrate that localized modulation of cell
                      rheology governs the transition of a slack, undulated
                      cell-cell contact (weak adhesion) to a mature, straight
                      junction (optimal adhesion). Cell pairs confined on
                      different geometries have heterogeneous elasticity maps and
                      control their own intrinsic rheology co-ordinately. More
                      compliant cell pairs grown on circles have slack contacts,
                      while stiffer triangular cell pairs favour straight
                      junctions with flanking contractile thin bundles.
                      Counter-intuitively, straighter cell-cell contacts have
                      reduced receptor density and less dynamic junctional actin,
                      suggesting an unusual adaptive mechano-response to stabilize
                      cell-cell adhesion. Our modelling informs that slack
                      junctions arise from failure of circular cell pairs to
                      increase their own intrinsic stiffness and resist the
                      pressures from the neighbouring cell. The inability to form
                      a straight junction can be reversed by increasing mechanical
                      stress artificially on stiffer substrates. Our data inform
                      on the minimal intrinsic rheology to generate a mature
                      junction and provide a springboard towards understanding
                      elements governing tissue-level mechanics.},
      cin          = {IBI-2},
      ddc          = {500},
      cid          = {I:(DE-Juel1)IBI-2-20200312},
      pnm          = {333 - Integrative Biomedizin (POF4-333) / 315 - Bildgebung
                      und Radioonkologie (POF4-315) / 5243 - Information
                      Processing in Distributed Systems (POF4-524) / DFG project
                      273723265 - Mechanosensation und Mechanoreaktion in
                      epidermalen Systemen},
      pid          = {G:(DE-HGF)POF4-333 / G:(DE-HGF)POF4-315 /
                      G:(DE-HGF)POF4-5243 / G:(GEPRIS)273723265},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35977954},
      UT           = {WOS:001124833500001},
      doi          = {10.1038/s41467-022-32102-9},
      url          = {https://juser.fz-juelich.de/record/909777},
}