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@PHDTHESIS{Fricke:909837,
      author       = {Fricke, Philipp Moritz},
      title        = {{E}stablishing regulatable expression systems in the acetic
                      acid bacterium {G}luconobacter oxydans 621{H}},
      volume       = {258},
      school       = {Univ. Düsseldorf},
      type         = {Dissertation},
      address      = {Jülich},
      publisher    = {Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag},
      reportid     = {FZJ-2022-03455},
      isbn         = {978-3-95806-642-7},
      series       = {Schriften des Forschungszentrums Jülich Reihe
                      Schlüsseltechnologien / Key Technologies},
      pages        = {VIII, 187},
      year         = {2022},
      note         = {Dissertation, Univ. Düsseldorf, 2022},
      abstract     = {Among industrially relevant microorganisms, the acetic acid
                      bacterium Gluconobacter oxydans is valued for its ability to
                      incompletely oxidize a vast number of carbohydrates
                      stereoand regio-specifically. Biotechnological production
                      processes involving G. oxydans strains so far utilized
                      exclusively constitutive target gene expression. Regulatable
                      promoters used in G. oxydans suffered from low induction
                      fold-changes and relatively high basal promoter activity
                      already when not induced. This study aimed to establish
                      regulatable promoter systems in G. oxydans that allow tuned
                      target gene expression in an effector-dependent manner. For
                      this purpose, expression plasmids were constructed to test
                      four well-characterized heterologous regulator-promoter
                      pairs in G. oxydans. Additionally, screenings were performed
                      to identify regulatable endogenous G. oxydans promoters
                      responding to a metabolite given as an external stimulus and
                      suitable for controlled gene expression.},
      cin          = {IBG-1},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)3 / PUB:(DE-HGF)11},
      urn          = {urn:nbn:de:0001-2022112326},
      url          = {https://juser.fz-juelich.de/record/909837},
}