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000909907 1001_ $$0P:(DE-Juel1)176325$$aHuwa, Nikolai$$b0
000909907 245__ $$aThe Crystal Structure of the Defense Conferring Rice Protein OsJAC1 Reveals a Carbohydrate Binding Site on the Dirigent-like Domain
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000909907 520__ $$aPesticides are routinely used to prevent severe losses in agriculture. This practice is under debate because of its potential negative environmental impact and selection of resistances in pathogens. Therefore, the development of disease resistant plants is mandatory. It was shown that the rice (Oryza sativa) protein OsJAC1 enhances resistance against different bacterial and fungal plant pathogens in rice, barley, and wheat. Recently we reported possible carbohydrate interaction partners for both domains of OsJAC1 (a jacalin-related lectin (JRL) and a dirigent (DIR) domain), however, a mechanistic understanding of its function is still lacking. Here, we report crystal structures for both individual domains and the complex of galactobiose with the DIR domain, which revealed a new carbohydrate binding motif for DIR proteins. Docking studies of the two domains led to a model of the full-length protein. Our findings offer insights into structure and binding properties of OsJAC1 and its possible function in pathogen resistance.
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000909907 536__ $$0G:(GEPRIS)369034981$$aDFG project 369034981 - Mechanismen der durch Dirigent/Jacalin-Proteinpaare hervorgerufenen Breitspektrumresistenz in Pflanzen gegen pilzliche Pathogene $$c369034981$$x2
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000909907 7001_ $$0P:(DE-Juel1)131988$$aWeiergräber, Oliver H.$$b1$$ufzj
000909907 7001_ $$0P:(DE-Juel1)176769$$aFejzagić, Alexander V.$$b2$$ufzj
000909907 7001_ $$00000-0003-1002-4180$$aKirsch, Christian$$b3
000909907 7001_ $$00000-0002-3691-0888$$aSchaffrath, Ulrich$$b4
000909907 7001_ $$0P:(DE-Juel1)128890$$aClassen, Thomas$$b5$$eCorresponding author
000909907 773__ $$0PERI:(DE-600)2701262-1$$a10.3390/biom12081126$$gVol. 12, no. 8, p. 1126 -$$n8$$p1126 -$$tBiomolecules$$v12$$x2218-273X$$y2022
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