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@ARTICLE{Huwa:909907,
      author       = {Huwa, Nikolai and Weiergräber, Oliver H. and Fejzagić,
                      Alexander V. and Kirsch, Christian and Schaffrath, Ulrich
                      and Classen, Thomas},
      title        = {{T}he {C}rystal {S}tructure of the {D}efense {C}onferring
                      {R}ice {P}rotein {O}s{JAC}1 {R}eveals a {C}arbohydrate
                      {B}inding {S}ite on the {D}irigent-like {D}omain},
      journal      = {Biomolecules},
      volume       = {12},
      number       = {8},
      issn         = {2218-273X},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2022-03510},
      pages        = {1126 -},
      year         = {2022},
      abstract     = {Pesticides are routinely used to prevent severe losses in
                      agriculture. This practice is under debate because of its
                      potential negative environmental impact and selection of
                      resistances in pathogens. Therefore, the development of
                      disease resistant plants is mandatory. It was shown that the
                      rice (Oryza sativa) protein OsJAC1 enhances resistance
                      against different bacterial and fungal plant pathogens in
                      rice, barley, and wheat. Recently we reported possible
                      carbohydrate interaction partners for both domains of OsJAC1
                      (a jacalin-related lectin (JRL) and a dirigent (DIR)
                      domain), however, a mechanistic understanding of its
                      function is still lacking. Here, we report crystal
                      structures for both individual domains and the complex of
                      galactobiose with the DIR domain, which revealed a new
                      carbohydrate binding motif for DIR proteins. Docking studies
                      of the two domains led to a model of the full-length
                      protein. Our findings offer insights into structure and
                      binding properties of OsJAC1 and its possible function in
                      pathogen resistance.},
      cin          = {IBI-7 / IBOC / IBG-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBI-7-20200312 / I:(DE-Juel1)IBOC-20090406 /
                      I:(DE-Juel1)IBG-1-20101118},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524) / 2171 - Biological and environmental resources
                      for sustainable use (POF4-217) / DFG project 369034981 -
                      Mechanismen der durch Dirigent/Jacalin-Proteinpaare
                      hervorgerufenen Breitspektrumresistenz in Pflanzen gegen
                      pilzliche Pathogene},
      pid          = {G:(DE-HGF)POF4-5241 / G:(DE-HGF)POF4-2171 /
                      G:(GEPRIS)369034981},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36009020},
      UT           = {WOS:000847001000001},
      doi          = {10.3390/biom12081126},
      url          = {https://juser.fz-juelich.de/record/909907},
}