%0 Journal Article
%A Qaim, Syed M.
%A Spahn, Ingo
%A Scholten, Bernhard
%A Spellerberg, Stefan
%A Neumaier, Bernd
%T The role of chemistry in accelerator-based production and separation of radionuclides as basis for radiolabelled compounds for medical applications
%J Radiochimica acta
%V 110
%N 6-9
%@ 0033-8230
%C Berlin
%I De Gruyter
%M FZJ-2022-03545
%P 707 - 724
%D 2022
%X Radiochemical separations used in large scale routine production of diagnostic and therapeutic radionuclides at a particle accelerator for patient care are briefly outlined. The role of chemistry at various stages of development of a production route of a novel radionuclide, namely nuclear data measurement, high-current targetry, chemical processing and quality control of the product, is discussed in detail. Special attention is paid to production of non-standard positron emitters (e.g. 44gSc, 64Cu, 68Ga, etc.) at a cyclotron and novel therapeutic radionuclides (e.g. 67Cu, 225Ac, etc.) at an accelerator. Some typical examples of radiochemical methods involved are presented.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000790949000001
%R 10.1515/ract-2022-0017
%U https://juser.fz-juelich.de/record/909955
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