TY  - JOUR
AU  - Qaim, Syed M.
AU  - Spahn, Ingo
AU  - Scholten, Bernhard
AU  - Spellerberg, Stefan
AU  - Neumaier, Bernd
TI  - The role of chemistry in accelerator-based production and separation of radionuclides as basis for radiolabelled compounds for medical applications
JO  - Radiochimica acta
VL  - 110
IS  - 6-9
SN  - 0033-8230
CY  - Berlin
PB  - ˜Deœ Gruyter
M1  - FZJ-2022-03545
SP  - 707 - 724
PY  - 2022
AB  - Radiochemical separations used in large scale routine production of diagnostic and therapeutic radionuclides at a particle accelerator for patient care are briefly outlined. The role of chemistry at various stages of development of a production route of a novel radionuclide, namely nuclear data measurement, high-current targetry, chemical processing and quality control of the product, is discussed in detail. Special attention is paid to production of non-standard positron emitters (e.g. 44gSc, 64Cu, 68Ga, etc.) at a cyclotron and novel therapeutic radionuclides (e.g. 67Cu, 225Ac, etc.) at an accelerator. Some typical examples of radiochemical methods involved are presented.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000790949000001
DO  - DOI:10.1515/ract-2022-0017
UR  - https://juser.fz-juelich.de/record/909955
ER  -