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@ARTICLE{Hardy:910107,
      author       = {Hardy, Aël and Kever, Larissa and Frunzke, Julia},
      title        = {{A}ntiphage small molecules produced by bacteria – beyond
                      protein-mediated defenses},
      journal      = {Trends in microbiology},
      volume       = {31},
      number       = {1},
      issn         = {0966-842X},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2022-03615},
      pages        = {92-106},
      year         = {2023},
      note         = {Biotechnologie 1},
      abstract     = {Bacterial populations face the constant threat of viral
                      predation exerted by bacteriophages (‘phages’). In
                      response, bacteria have evolved a wide range of defense
                      mechanisms against phage challenges. Yet the vast majority
                      of antiphage defense systems described until now are
                      mediated by proteins or RNA complexes acting at the
                      single-cell level. Here, we review small molecule-based
                      defense strategies against phage infection, with a focus on
                      the antiphage molecules described recently. Importantly,
                      inhibition of phage infection by excreted small molecules
                      has the potential to protect entire bacterial communities,
                      highlighting the ecological significance of these antiphage
                      strategies. Considering the immense repertoire of bacterial
                      metabolites, we envision that the list of antiphage small
                      molecules will be further expanded in the future.},
      cin          = {IBG-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {2171 - Biological and environmental resources for
                      sustainable use (POF4-217) / DFG project 464434020 -
                      Inhibierung der Phageninfektion durch aktinobakterielle
                      Sekundärmetabolite (464434020)},
      pid          = {G:(DE-HGF)POF4-2171 / G:(GEPRIS)464434020},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36038409},
      UT           = {WOS:000912531000001},
      doi          = {10.1016/j.tim.2022.08.001},
      url          = {https://juser.fz-juelich.de/record/910107},
}