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| Hauptseite > Publikationsdatenbank > An 89Zr-Labeled PSMA Tracer for PET/CT Imaging of Prostate Cancer Patients > print |
| Hauptseite > Publikationsdatenbank > An 89Zr-Labeled PSMA Tracer for PET/CT Imaging of Prostate Cancer Patients > print |
| 001 | 910154 | ||
| 005 | 20230123110657.0 | ||
| 024 | 7 | _ | |a 10.2967/jnumed.121.262290 |2 doi |
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| 100 | 1 | _ | |a Dietlein, Felix |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a An 89Zr-Labeled PSMA Tracer for PET/CT Imaging of Prostate Cancer Patients |
| 260 | _ | _ | |a New York, NY |c 2022 |b Soc. |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a The short half-life of existing prostate-specificmembraneantigen (PSMA) tracers limits their time for internalization into tumor cells after injection, which is an essential prerequisite for robust detection of tumor lesions with low PSMA expression on PET/CT scans. Because of its longer half-life, the 89Zr-labeled ligand 89Zr-PSMA-DFO allows acquisition of PET scans up to 6 d after injection, thereby overcoming the above limitation. We investigated whether 89Zr-PSMA-DFO allowed more sensitive detection of weak PSMA-positive prostate cancer lesions. Methods: We selected 14 prostate cancer patients with biochemical recurrence who exhibited no PSMA-positive lesions on a PET scan acquired with existing PSMA tracers (68Ga-PSMA-11, 18F-JK-PSMA-7). Within 5 wk after the negative scan result, we obtained a second PSMA PET scan using 89Zr-PSMA-DFO (117 6 16 MBq, PET acquisition within 6 d of injection). Results: 89Zr-PSMADFO detected 15 PSMA-positive lesions in 8 of 14 patients, who had a PET-negative reading of their initial PET scans with existing tracers. In these 8 patients, the new scans revealed localized recurrence of disease (3/8), metastases in lymph nodes (3/8), or lesions at distant sites (2/8). On the basis of these results, patients received lesiontargeted radiotherapies (5/8), androgen deprivation therapies (2/8), or no therapy (1/8). The plausibility of 14 of 15 lesions was supported by histology, clinical follow-up after radiotherapy, or subsequent imaging. Furthermore, comparison of the 15 89Zr-PSMA-DFO–positive lesions with their correlates on the original PET scan revealed that established tracers exhibited mild accumulation in 7 of 15 lesions; however, contrast-to-noise ratios were too low for robust detection of these lesions (contrast-to-noise ratios, 2.4 6 3.7 for established tracers vs. 10.2 6 8.5 for89Zr-PSMA-DFO, P 5 0.0014). The SUVmax of the 15 89ZrPSMA-DFO–positive lesions (11.5 6 5.8) was significantly higher than the SUVmax on the original PET scans (4.7 6 2.8, P5 0.0001). Kidneys were the most exposed organ, with doses of 3.3 6 0.7 mGy/MBq. The effective dose was 0.15 6 0.04 mSv/MBq. Conclusion: In patients with weak PSMA expression, a longer period of time might be needed for ligand internalization than that offered by existing PSMA tracers to make lesions visible on PET/CT scans. Hence, 89ZrPSMA-DFO might be of significant benefit to patients in whom the search for weak PSMA-positive lesions is challenging. Radiation exposure should be weighed against the potential benefitof metastasis-directed therapy or salvage radiotherapy, which weinitiated in 36% (5/14) of our patients based on their 89Zr-PSMA-DFO PET scans. |
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| 700 | 1 | _ | |a Kobe, Carsten |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Vázquez, Sergio Muñoz |0 P:(DE-HGF)0 |b 2 |
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| 700 | 1 | _ | |a Dietlein, Markus |0 P:(DE-HGF)0 |b 10 |e Corresponding author |
| 773 | _ | _ | |a 10.2967/jnumed.121.262290 |g Vol. 63, no. 4, p. 573 - 583 |0 PERI:(DE-600)2040222-3 |n 4 |p 573 - 583 |t Journal of nuclear medicine |v 63 |y 2022 |x 0022-3123 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/910154/files/jnumed.121.262290.full.pdf |y OpenAccess |
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