TY  - JOUR
AU  - Wollring, Michael M
AU  - Werner, Jan-Michael
AU  - Bauer, Elena K
AU  - Tscherpel, Caroline
AU  - Ceccon, Garry S
AU  - Lohmann, Philipp
AU  - Stoffels, Gabriele
AU  - Langen, Karl-Josef
AU  - Kabbasch, Christoph
AU  - Goldbrunner, Roland
AU  - Fink, Gereon R
AU  - Galldiks, Norbert
TI  - Prediction of response to lomustine-based chemotherapy in glioma patients at recurrence using MRI and FET PET
JO  - Neuro-Oncology
VL  - 25
IS  - 5
SN  - 1522-8517
CY  - Oxford
PB  - Oxford Univ. Press
M1  - FZJ-2022-03683
SP  - 984–994
PY  - 2023
AB  - BackgroundWe evaluated O-(2-[18F]fluoroethyl)-l-tyrosine (FET) PET and MRI for early response assessment in recurrent glioma patients treated with lomustine-based chemotherapy.MethodsThirty-six adult patients with WHO CNS grade 3 or 4 gliomas (glioblastoma, 69%) at recurrence (median number of recurrences, 1; range, 1–3) were retrospectively identified. Besides MRI, serial FET PET scans were performed at baseline and early after chemotherapy initiation (not later than two cycles). Tumor-to-brain ratios (TBR), metabolic tumor volumes (MTV), the occurrence of new distant hotspots with a mean TBR >1.6 at follow-up, and the dynamic parameter time-to-peak were derived from all FET PET scans. PET parameter thresholds were defined using ROC analyses to predict PFS of ≥6 months and OS of ≥12 months. MRI response assessment was based on RANO criteria. The predictive values of FET PET parameters and RANO criteria were subsequently evaluated using univariate and multivariate survival estimates.ResultsAfter treatment initiation, the median follow-up time was 11 months (range, 3–71 months). Relative changes of TBR, MTV, and RANO criteria predicted a significantly longer PFS (all P ≤ .002) and OS (all P ≤ .045). At follow-up, the occurrence of new distant hotspots (n ≥ 1) predicted a worse outcome, with significantly shorter PFS (P = .005) and OS (P < .001). Time-to-peak changes did not predict a significantly longer survival. Multivariate survival analyses revealed that new distant hotspots at follow-up FET PET were most potent in predicting non-response (P < .001; HR, 8.578).ConclusionsData suggest that FET PET provides complementary information to RANO criteria for response evaluation of lomustine-based chemotherapy early after treatment initiation.
LB  - PUB:(DE-HGF)16
C6  - 36215231
UR  - <Go to ISI:>//WOS:000881636600001
DO  - DOI:10.1093/neuonc/noac229
UR  - https://juser.fz-juelich.de/record/910206
ER  -