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@ARTICLE{Wollring:910206,
      author       = {Wollring, Michael M and Werner, Jan-Michael and Bauer,
                      Elena K and Tscherpel, Caroline and Ceccon, Garry S and
                      Lohmann, Philipp and Stoffels, Gabriele and Langen,
                      Karl-Josef and Kabbasch, Christoph and Goldbrunner, Roland
                      and Fink, Gereon R and Galldiks, Norbert},
      title        = {{P}rediction of response to lomustine-based chemotherapy in
                      glioma patients at recurrence using {MRI} and {FET} {PET}},
      journal      = {Neuro-Oncology},
      volume       = {25},
      number       = {5},
      issn         = {1522-8517},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2022-03683},
      pages        = {984–994},
      year         = {2023},
      abstract     = {BackgroundWe evaluated O-(2-[18F]fluoroethyl)-l-tyrosine
                      (FET) PET and MRI for early response assessment in recurrent
                      glioma patients treated with lomustine-based
                      chemotherapy.MethodsThirty-six adult patients with WHO CNS
                      grade 3 or 4 gliomas (glioblastoma, $69\%)$ at recurrence
                      (median number of recurrences, 1; range, 1–3) were
                      retrospectively identified. Besides MRI, serial FET PET
                      scans were performed at baseline and early after
                      chemotherapy initiation (not later than two cycles).
                      Tumor-to-brain ratios (TBR), metabolic tumor volumes (MTV),
                      the occurrence of new distant hotspots with a mean TBR >1.6
                      at follow-up, and the dynamic parameter time-to-peak were
                      derived from all FET PET scans. PET parameter thresholds
                      were defined using ROC analyses to predict PFS of ≥6
                      months and OS of ≥12 months. MRI response assessment was
                      based on RANO criteria. The predictive values of FET PET
                      parameters and RANO criteria were subsequently evaluated
                      using univariate and multivariate survival
                      estimates.ResultsAfter treatment initiation, the median
                      follow-up time was 11 months (range, 3–71 months).
                      Relative changes of TBR, MTV, and RANO criteria predicted a
                      significantly longer PFS (all P ≤ .002) and OS (all P ≤
                      .045). At follow-up, the occurrence of new distant hotspots
                      (n ≥ 1) predicted a worse outcome, with significantly
                      shorter PFS (P = .005) and OS (P < .001). Time-to-peak
                      changes did not predict a significantly longer survival.
                      Multivariate survival analyses revealed that new distant
                      hotspots at follow-up FET PET were most potent in predicting
                      non-response (P < .001; HR, 8.578).ConclusionsData suggest
                      that FET PET provides complementary information to RANO
                      criteria for response evaluation of lomustine-based
                      chemotherapy early after treatment initiation.},
      cin          = {INM-4 / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-3-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525) / 5251 - Multilevel Brain
                      Organization and Variability (POF4-525) / 5252 - Brain
                      Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253 / G:(DE-HGF)POF4-5251 /
                      G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36215231},
      UT           = {WOS:000881636600001},
      doi          = {10.1093/neuonc/noac229},
      url          = {https://juser.fz-juelich.de/record/910206},
}