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000910348 0247_ $$2doi$$a10.1016/j.diagmicrobio.2022.115800
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000910348 1001_ $$0P:(DE-HGF)0$$aLübke, Nadine$$b0$$eCorresponding author
000910348 245__ $$aQuantitative analysis of different respiratory specimens on two automated test systems for detection of SARS-CoV-2 RNA
000910348 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2023
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000910348 520__ $$aMolecular testing of SARS-CoV-2 RNA is essential during the pandemic. Here, we compared the results of different respiratory specimens including anterior nasal swabs, pharyngeal swabs, saliva swabs, and gargle lavage samples to nasopharyngeal swabs on two automated SARS-CoV-2 test systems. Samples were collected and tested simultaneously from a total of 36 hospitalized symptomatic COVID-19 patients. Detection and quantification of SARS-CoV-2 was performed on cobas®6800 (Roche) and NeuMoDx™ (Qiagen) systems. Both assays showed reliable detection and quantification of SARS-CoV-2 RNA, with nasopharyngeal swabs showing the highest sensitivity. SARS-CoV-2 RNA concentrations in other respiratory specimens were lower (mean 2.5 log10 copies/ml) or even undetectable in up to 20%. These data clearly indicate that not all respiratory materials are equally suitable for the management of hospitalized patients, especially, in the late phase of COVID-19, when the viral phase subsides and inflammation becomes the predominant factor, making detection of even lower viral loads increasingly important.
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000910348 7001_ $$0P:(DE-HGF)0$$aRepges, Katharina$$b1
000910348 7001_ $$0P:(DE-HGF)0$$aMenne, Christopher$$b2
000910348 7001_ $$0P:(DE-HGF)0$$aWalker, Andreas$$b3
000910348 7001_ $$0P:(DE-HGF)0$$aJensen, Björn-Erik O.$$b4
000910348 7001_ $$0P:(DE-HGF)0$$aFreise, Noemi F.$$b5
000910348 7001_ $$0P:(DE-HGF)0$$aGliga, Smaranda$$b6
000910348 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon$$b7$$ufzj
000910348 7001_ $$0P:(DE-HGF)0$$aBosse, Hans Martin$$b8
000910348 7001_ $$0P:(DE-HGF)0$$aAdams, Ortwin$$b9
000910348 7001_ $$0P:(DE-HGF)0$$aTimm, Jörg$$b10
000910348 773__ $$0PERI:(DE-600)2026024-6$$a10.1016/j.diagmicrobio.2022.115800$$gVol. 105, no. 1, p. 115800 -$$n1$$p115800 -$$tDiagnostic microbiology and infectious disease$$v105$$x0732-8893$$y2023
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