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@ARTICLE{Santarnecchi:910562,
      author       = {Santarnecchi, Emiliano and Sprugnoli, Giulia and Sicilia,
                      Isabella and Dukart, Jürgen and Neri, Francesco and
                      Romanella, Sara M. and Cerase, Alfonso and Vatti, Giampaolo
                      and Rocchi, Raffaele and Rossi, Alessandro},
      title        = {{T}halamic altered spontaneous activity and connectivity in
                      obstructive sleep apnea syndrome},
      journal      = {Journal of neuroimaging},
      volume       = {32},
      number       = {2},
      issn         = {1051-2284},
      address      = {Berlin [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {FZJ-2022-03940},
      pages        = {314 - 327},
      year         = {2022},
      abstract     = {Background and PurposeObstructive sleep apnea (OSA)
                      syndrome is a sleep disorder characterized by excessive
                      snoring, repetitive apneas, and nocturnal arousals, that
                      leads to fragmented sleep and intermittent nocturnal
                      hypoxemia. Morphometric and functional brain alterations in
                      cortical and subcortical structures have been documented in
                      these patients via magnetic resonance imaging (MRI), even if
                      correlational data between the alterations in the brain and
                      cognitive and clinical indexes are still not
                      reported.MethodsWe examined the impact of OSA on brain
                      spontaneous activity by measuring the fractional amplitude
                      of low-frequency fluctuations (fALFF) in resting-state
                      functional MRI data of 20 drug-naïve patients with OSA
                      syndrome and 20 healthy controls matched for age, gender,
                      and body mass index.ResultsPatients showed a pattern of
                      significantly abnormal subcortical functional activity as
                      compared to controls, with increased activity selectively
                      involving the thalami, specifically their intrinsic nuclei
                      connected to somatosensory and motor-premotor cortical
                      regions. Using these nuclei as seed regions, the subsequent
                      functional connectivity analysis highlighted an increase in
                      patients’ thalamocortical connectivity at rest.
                      Additionally, the correlation between fALFF and
                      polysomnographic data revealed a possible link between OSA
                      severity and fALFF of regions belonging to the central
                      autonomic network.ConclusionsOur results suggest a
                      hyperactivation in thalamic diurnal activity in patients
                      with OSA syndrome, which we interpret as a possible
                      consequence of increased thalamocortical circuitry
                      activation during nighttime due to repeated arousals.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34964182},
      UT           = {WOS:000735199700001},
      doi          = {10.1111/jon.12952},
      url          = {https://juser.fz-juelich.de/record/910562},
}