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@ARTICLE{Schlter:910570,
      author       = {Schlüter, Caroline and Fraenz, Christoph and Friedrich,
                      Patrick and Güntürkün, Onur and Genç, Erhan},
      title        = {{N}eurite density imaging in amygdala nuclei reveals
                      interindividual differences in neuroticism},
      journal      = {Human brain mapping},
      volume       = {43},
      number       = {6},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2022-03948},
      pages        = {2051 - 2063},
      year         = {2022},
      abstract     = {Neuroticism is known to have significant health
                      implications. While previous research revealed that
                      interindividual differences in the amygdala function are
                      associated with interindividual differences in neuroticism,
                      the impact of the amygdala's structure and especially
                      microstructure on variations in neuroticism remains unclear.
                      Here, we present the first study using NODDI to examine the
                      association between the in vivo microstructural architecture
                      of the amygdala and neuroticism at the level of neurites.
                      We, therefore, acquired brain images from 221 healthy
                      participants using advanced multi-shell diffusion-weighted
                      imaging. Because the amygdala comprises several nuclei, we,
                      moreover, used a high-resolution T1 image to automatically
                      segment the amygdala into eight different nuclei.
                      Neuroticism and its facets have been assessed using the
                      NEO-PI-R. Finally, we associated neuroticism and its facets
                      with the volume and microstructure of the amygdala nuclei.
                      Statistical analysis revealed that lower neurite density in
                      the lateral amygdala nucleus (La) was significantly
                      associated with higher scores in depression, one of the six
                      neuroticism facets. The La is the sensory relay of the
                      amygdala, filtering incoming information based on previous
                      experiences. Reduced neurite density and related changes in
                      the dendritic structure of the La could impair its filtering
                      function. This again might cause harmless sensory
                      information to be misevaluated as threatening and lead to
                      the altered amygdala responsivity as reported in previous
                      studies investigating the functional correlates of
                      neuroticism and neuroticism-related disorders like
                      depression.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35049113},
      UT           = {WOS:000744500000001},
      doi          = {10.1002/hbm.25775},
      url          = {https://juser.fz-juelich.de/record/910570},
}