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@ARTICLE{Blchl:910573,
      author       = {Blöchl, Maria and Schaare, Lina and Kunzmann, Ute and
                      Nestler, Steffen},
      title        = {{T}he {A}ge-{D}ependent {A}ssociation {B}etween {V}ascular
                      {R}isk {F}actors and {D}epressed {M}ood},
      journal      = {The journals of gerontology / B},
      volume       = {77},
      number       = {2},
      issn         = {1079-5014},
      address      = {Oxford [u.a.]},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2022-03951},
      pages        = {284 - 294},
      year         = {2022},
      abstract     = {ObjectivesCumulative burden of vascular risk factors (VRFs)
                      has been linked to an increased risk of depressed mood.
                      However, the role of age in this association is still
                      unclear. Here, we investigated whether VRF burden is
                      associated with levels and changes in depressed mood and
                      whether these associations become stronger or weaker from
                      mid- to later life.MethodWe used longitudinal data from
                      5,689 participants (52–89 years) of the English
                      Longitudinal Study of Ageing. A composite score incorporated
                      the presence of 5 VRFs: hypertension, diabetes, smoking,
                      obesity, and hypercholesterolemia. Second-order latent
                      growth models were used to test whether levels and changes
                      of depressed mood differed as a function of baseline VRF
                      burden, and whether these associations were moderated by
                      age.ResultsBaseline VRF burden showed a small association
                      with higher levels of depressed mood (estimate = 0.081;
                      $95\%$ CI: 0.024, 0.138, p = .005). This association varied
                      with age, such that it was stronger in midlife compared to
                      later life (estimate = −0.007; $95\%$ CI: −0.013,
                      −0.002, p = .017). There was no evidence that VRF burden
                      was associated with changes in depressed mood.DiscussionOur
                      findings suggest that VRF burden in midlife, but less so in
                      later life, predicts individual differences in depressed
                      mood. These findings are consistent with reports on the
                      importance of midlife VRFs and support the idea that
                      promotion of vascular health in this age group or earlier in
                      life may be critical to maintain mental health across
                      adulthood.},
      cin          = {INM-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34080633},
      UT           = {WOS:000753117200003},
      doi          = {10.1093/geronb/gbab063},
      url          = {https://juser.fz-juelich.de/record/910573},
}