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@ARTICLE{Lapate:910587,
      author       = {Lapate, Regina C. and Ballard, Ian C. and Heckner, Marisa
                      K. and D'Esposito, Mark},
      title        = {{E}motional {C}ontext {S}culpts {A}ction {G}oal
                      {R}epresentations in the {L}ateral {F}rontal {P}ole},
      journal      = {The journal of neuroscience},
      volume       = {42},
      number       = {8},
      issn         = {0270-6474},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {FZJ-2022-03965},
      pages        = {1529 - 1541},
      year         = {2022},
      abstract     = {Emotional states provide an ever-present source of
                      contextual information that should inform behavioral goals.
                      Despite the ubiquity of emotional signals in our
                      environment, the neural mechanisms underlying their
                      influence on goal-directed action remains unclear. Prior
                      work suggests that the lateral frontal pole (FPl) is
                      uniquely positioned to integrate affective information into
                      cognitive control representations. We used pattern
                      similarity analysis to examine the content of
                      representations in FPl and interconnected mid-lateral
                      prefrontal and amygdala circuitry. Healthy participants (n =
                      37; n = 21 females) were scanned while undergoing an
                      event-related Affective Go/No-Go task, which requires
                      goal-oriented action selection during emotional processing.
                      We found that FPl contained conjunctive emotion–action
                      goal representations that were related to successful
                      cognitive control during emotional processing. These
                      representations differed from conjunctive emotion–action
                      goal representations found in the basolateral amygdala.
                      While robust action goal representations were present in
                      mid-lateral prefrontal cortex, they were not modulated by
                      emotional valence. Finally, converging results from
                      functional connectivity and multivoxel pattern analyses
                      indicated that FPl emotional valence signals likely
                      originated from interconnected subgenual anterior cingulate
                      cortex (ACC) (BA25), which was in turn functionally coupled
                      with the amygdala. Thus, our results identify a key pathway
                      by which internal emotional states influence goal-directed
                      behavior.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34969868},
      UT           = {WOS:000768775000001},
      doi          = {10.1523/JNEUROSCI.1522-21.2021},
      url          = {https://juser.fz-juelich.de/record/910587},
}