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@INPROCEEDINGS{Foerges:910591,
      author       = {Foerges, Anna Linea and Elmenhorst, Eva-Maria and Lange,
                      Denise and Baur, Diego and Beer, Simone and Kroll, Tina and
                      Neumaier, Bernd and Aeschbach, Daniel and Bauer, Andreas and
                      Landolt, Hans-Peter and Elmenhorst, David},
      title        = {{D}oes repeated coffee consumption during chronic sleep
                      restriction affect {A}1 adenosine receptor availability in
                      humans?},
      reportid     = {FZJ-2022-03969},
      year         = {2022},
      abstract     = {Objectives:Adenosine and cerebral adenosine A1 (A1AR) and
                      A2A receptors are important modulators of the sleep-wake
                      cycle and regulate to some extent the sleep-wake
                      homeostasis. Acute sleep deprivation has been shown to
                      result in an upregulation of A1ARs in human and rat brains.
                      The stimulating effects of caffeine are evoked through
                      non-selective antagonism at adenosine receptors. Using
                      positron emission tomography (PET), we investigate the
                      effect of repeated coffee consumption during chronic sleep
                      restriction and subsequent coffee abstinence after recovery
                      sleep on cerebral A1AR availability and occupancy in
                      humans.Methods:Thirty healthy volunteers (28±5 years, 15f)
                      completed an in-lab study including three [18F]CPFPX PET
                      scans to determine cerebral A1AR availability after
                      subsequent exposure to rested (3 nights with 8h time in bed
                      (TIB)), chronically sleep restricted (5 nights with 5h TIB),
                      and recovery (one night with 8h TIB) conditions.
                      Participants either consumed freshly brewed coffee (n = 17)
                      or decaffeinated coffee (n = 13) during 5 days of sleep
                      restriction (prior caffeine abstinence > 10 days). Regular
                      coffee contained 200 mg caffeine at 7.30 a.m. and 100 mg
                      caffeine at 2.00 p.m., decaffeinated coffee contained 4 mg
                      and 2 mg, respectively. PET scans were conducted at the same
                      time of day under caffeine-abstinent rested conditions,
                      roughly 7h after the latest coffee intake after sleep
                      restriction, and after ~ 31h of coffee abstention after
                      recovery. Caffeine levels in saliva were determined
                      repeatedly. Cerebral A1AR availability was quantified by
                      distribution volume (VT) and occupancy levels were
                      calculated by applying the Lassen plot including cortical
                      and subcortical areas, cerebellum, and pons.Results:In the
                      decaffeinated coffee group, no differences in cerebral A1AR
                      availability were found between baseline condition, 5 days
                      of sleep restriction and one night of recovery sleep.
                      Repeated administration of regular coffee resulted in a
                      displacement of [18F]CPFPX binding of 19 ± 13 $\%$ on
                      average. One day after coffee abstention and recovery sleep,
                      VT values did not differ from baseline.Conclusions:Our data
                      suggest that neither chronic sleep restriction for 5 days
                      nor combination with repeated caffeine consumption result in
                      a persistent change in the regulation of cerebral A1AR
                      availability.Financial support:The work was supported by the
                      Institute for Scientific Information on Coffee, the Swiss
                      National Science Foundation (# $320030_163439)$ and
                      respective institutional funds.},
      month         = {Sep},
      date          = {2022-09-27},
      organization  = {The 26th Conference of the European
                       Sleep Research Society, Athens
                       (Greece), 27 Sep 2022 - 30 Sep 2022},
      subtyp        = {After Call},
      cin          = {INM-2 / INM-5},
      cid          = {I:(DE-Juel1)INM-2-20090406 / I:(DE-Juel1)INM-5-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)24},
      url          = {https://juser.fz-juelich.de/record/910591},
}