000910708 001__ 910708
000910708 005__ 20230123110716.0
000910708 0247_ $$2doi$$a10.1093/schbul/sbab151
000910708 0247_ $$2ISSN$$a0586-7614
000910708 0247_ $$2ISSN$$a1745-1701
000910708 0247_ $$2Handle$$a2128/32320
000910708 0247_ $$2pmid$$a35137221
000910708 0247_ $$2WOS$$aWOS:000791825400005
000910708 037__ $$aFZJ-2022-04079
000910708 082__ $$a610
000910708 1001_ $$0P:(DE-Juel1)187157$$aHettwer, Meike D$$b0
000910708 245__ $$aEvidence From Imaging Resilience Genetics for a Protective Mechanism Against Schizophrenia in the Ventral Visual Pathway
000910708 260__ $$aOxford$$bOxford Univ. Press$$c2022
000910708 3367_ $$2DRIVER$$aarticle
000910708 3367_ $$2DataCite$$aOutput Types/Journal article
000910708 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1667469236_9517
000910708 3367_ $$2BibTeX$$aARTICLE
000910708 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000910708 3367_ $$00$$2EndNote$$aJournal Article
000910708 520__ $$aIntroductionIlluminating neurobiological mechanisms underlying the protective effect of recently discovered common genetic resilience variants for schizophrenia is crucial for more effective prevention efforts. Current models implicate adaptive neuroplastic changes in the visual system and their pro-cognitive effects as a schizophrenia resilience mechanism. We investigated whether common genetic resilience variants might affect brain structure in similar neural circuits.MethodUsing structural magnetic resonance imaging, we measured the impact of an established schizophrenia polygenic resilience score (PRSResilience) on cortical volume, thickness, and surface area in 101 healthy subjects and in a replication sample of 33 224 healthy subjects (UK Biobank).FindingWe observed a significant positive whole-brain correlation between PRSResilience and cortical volume in the right fusiform gyrus (FFG) (r = 0.35; P = .0004). Post-hoc analyses in this cluster revealed an impact of PRSResilience on cortical surface area. The replication sample showed a positive correlation between PRSResilience and global cortical volume and surface area in the left FFG.ConclusionOur findings represent the first evidence of a neurobiological correlate of a genetic resilience factor for schizophrenia. They support the view that schizophrenia resilience emerges from strengthening neural circuits in the ventral visual pathway and an increased capacity for the disambiguation of social and nonsocial visual information. This may aid psychosocial functioning, ameliorate the detrimental effects of subtle perceptual and cognitive disturbances in at-risk individuals, and facilitate coping with the cognitive and psychosocial consequences of stressors. Our results thus provide a novel link between visual cognition, the vulnerability-stress concept, and schizophrenia resilience models.
000910708 536__ $$0G:(DE-HGF)POF4-5252$$a5252 - Brain Dysfunction and Plasticity (POF4-525)$$cPOF4-525$$fPOF IV$$x0
000910708 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
000910708 7001_ $$0P:(DE-HGF)0$$aLancaster, Thomas M$$b1
000910708 7001_ $$0P:(DE-HGF)0$$aRaspor, Eva$$b2
000910708 7001_ $$0P:(DE-HGF)0$$aHahn, Peter K$$b3
000910708 7001_ $$0P:(DE-HGF)0$$aMota, Nina Roth$$b4
000910708 7001_ $$0P:(DE-HGF)0$$aSinger, Wolf$$b5
000910708 7001_ $$0P:(DE-HGF)0$$aReif, Andreas$$b6
000910708 7001_ $$0P:(DE-HGF)0$$aLinden, David E J$$b7
000910708 7001_ $$0P:(DE-HGF)0$$aBittner, Robert A$$b8$$eCorresponding author
000910708 773__ $$0PERI:(DE-600)2180196-4$$a10.1093/schbul/sbab151$$gVol. 48, no. 3, p. 551 - 562$$n3$$p551 - 562$$tSchizophrenia bulletin$$v48$$x0586-7614$$y2022
000910708 8564_ $$uhttps://juser.fz-juelich.de/record/910708/files/2021.07.23.21261045.full.pdf$$yOpenAccess
000910708 909CO $$ooai:juser.fz-juelich.de:910708$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000910708 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)187157$$aForschungszentrum Jülich$$b0$$kFZJ
000910708 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)187157$$a Department of Psychiatry, Psychosomatic Medicine, and Psychotherapy, University Hospital Frankfurt, Goethe University , Frankfurt am Main$$b0
000910708 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)187157$$a Max Planck School of Cognition, Max Planck Institute for Human Cognitive and Brain Sciences , Leipzig$$b0
000910708 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)187157$$a HHU Düsseldorf$$b0
000910708 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Department of Psychiatry, Psychosomatic Medicine, and Psychotherapy, University Hospital Frankfurt, Goethe University , Frankfurt am Main$$b8
000910708 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5252$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
000910708 9141_ $$y2022
000910708 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-01-27
000910708 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-01-27
000910708 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-01-27
000910708 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000910708 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2022-11-11$$wger
000910708 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-11
000910708 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-11
000910708 915__ $$0StatID:(DE-HGF)1180$$2StatID$$aDBCoverage$$bCurrent Contents - Social and Behavioral Sciences$$d2022-11-11
000910708 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-11
000910708 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-11
000910708 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2022-11-11
000910708 915__ $$0StatID:(DE-HGF)0130$$2StatID$$aDBCoverage$$bSocial Sciences Citation Index$$d2022-11-11
000910708 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bSCHIZOPHRENIA BULL : 2021$$d2022-11-11
000910708 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-11
000910708 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bSCHIZOPHRENIA BULL : 2021$$d2022-11-11
000910708 920__ $$lyes
000910708 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0
000910708 980__ $$ajournal
000910708 980__ $$aVDB
000910708 980__ $$aUNRESTRICTED
000910708 980__ $$aI:(DE-Juel1)INM-7-20090406
000910708 9801_ $$aFullTexts