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@ARTICLE{Hettwer:910708,
      author       = {Hettwer, Meike D and Lancaster, Thomas M and Raspor, Eva
                      and Hahn, Peter K and Mota, Nina Roth and Singer, Wolf and
                      Reif, Andreas and Linden, David E J and Bittner, Robert A},
      title        = {{E}vidence {F}rom {I}maging {R}esilience {G}enetics for a
                      {P}rotective {M}echanism {A}gainst {S}chizophrenia in the
                      {V}entral {V}isual {P}athway},
      journal      = {Schizophrenia bulletin},
      volume       = {48},
      number       = {3},
      issn         = {0586-7614},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2022-04079},
      pages        = {551 - 562},
      year         = {2022},
      abstract     = {IntroductionIlluminating neurobiological mechanisms
                      underlying the protective effect of recently discovered
                      common genetic resilience variants for schizophrenia is
                      crucial for more effective prevention efforts. Current
                      models implicate adaptive neuroplastic changes in the visual
                      system and their pro-cognitive effects as a schizophrenia
                      resilience mechanism. We investigated whether common genetic
                      resilience variants might affect brain structure in similar
                      neural circuits.MethodUsing structural magnetic resonance
                      imaging, we measured the impact of an established
                      schizophrenia polygenic resilience score (PRSResilience) on
                      cortical volume, thickness, and surface area in 101 healthy
                      subjects and in a replication sample of 33 224 healthy
                      subjects (UK Biobank).FindingWe observed a significant
                      positive whole-brain correlation between PRSResilience and
                      cortical volume in the right fusiform gyrus (FFG) (r = 0.35;
                      P = .0004). Post-hoc analyses in this cluster revealed an
                      impact of PRSResilience on cortical surface area. The
                      replication sample showed a positive correlation between
                      PRSResilience and global cortical volume and surface area in
                      the left FFG.ConclusionOur findings represent the first
                      evidence of a neurobiological correlate of a genetic
                      resilience factor for schizophrenia. They support the view
                      that schizophrenia resilience emerges from strengthening
                      neural circuits in the ventral visual pathway and an
                      increased capacity for the disambiguation of social and
                      nonsocial visual information. This may aid psychosocial
                      functioning, ameliorate the detrimental effects of subtle
                      perceptual and cognitive disturbances in at-risk
                      individuals, and facilitate coping with the cognitive and
                      psychosocial consequences of stressors. Our results thus
                      provide a novel link between visual cognition, the
                      vulnerability-stress concept, and schizophrenia resilience
                      models.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35137221},
      UT           = {WOS:000791825400005},
      doi          = {10.1093/schbul/sbab151},
      url          = {https://juser.fz-juelich.de/record/910708},
}