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000910710 1001_ $$0P:(DE-HGF)0$$aHong, Seok-Jun$$b0$$eCorresponding author
000910710 245__ $$aA convergent structure–function substrate of cognitive imbalances in autism
000910710 260__ $$aOxford$$bOxford Univ. Press$$c2023
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000910710 520__ $$aBackground: Autism spectrum disorder (ASD) is a common neurodevelopmental diagnosis showing substantial phenotypic heterogeneity. A leading example can be found in verbal and nonverbal cognitive skills, which vary from elevated to impaired compared with neurotypical individuals. Moreover, deficits in verbal profiles often coexist with normal or superior performance in the nonverbal domain.Methods: To study brain substrates underlying cognitive imbalance in ASD, we capitalized categorical and dimensional IQ profiling as well as multimodal neuroimaging.Results: IQ analyses revealed a marked verbal to nonverbal IQ imbalance in ASD across 2 datasets (Dataset-1: 155 ASD, 151 controls; Dataset-2: 270 ASD, 490 controls). Neuroimaging analysis in Dataset-1 revealed a structure-function substrate of cognitive imbalance, characterized by atypical cortical thickening and altered functional integration of language networks alongside sensory and higher cognitive areas.Conclusion: Although verbal and nonverbal intelligence have been considered as specifiers unrelated to autism diagnosis, our results indicate that intelligence disparities are accentuated in ASD and reflected by a consistent structure-function substrate affecting multiple brain networks. Our findings motivate the incorporation of cognitive imbalances in future autism research, which may help to parse the phenotypic heterogeneity and inform intervention-oriented subtyping in ASD.
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000910710 7001_ $$0P:(DE-HGF)0$$aMottron, Laurent$$b1
000910710 7001_ $$0P:(DE-HGF)0$$aPark, Bo-yong$$b2
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000910710 7001_ $$0P:(DE-Juel1)173843$$aValk, Sofie L$$b4
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000910710 7001_ $$0P:(DE-HGF)0$$aLarivière, Sara$$b6
000910710 7001_ $$0P:(DE-HGF)0$$aVos de Wael, Reinder$$b7
000910710 7001_ $$0P:(DE-HGF)0$$aDegré-Pelletier, Janie$$b8
000910710 7001_ $$0P:(DE-HGF)0$$aSoulieres, Isabelle$$b9
000910710 7001_ $$0P:(DE-HGF)0$$aRamphal, Bruce$$b10
000910710 7001_ $$0P:(DE-HGF)0$$aMargolis, Amy$$b11
000910710 7001_ $$0P:(DE-HGF)0$$aMilham, Michael$$b12
000910710 7001_ $$0P:(DE-HGF)0$$aDi Martino, Adriana$$b13
000910710 7001_ $$0P:(DE-HGF)0$$aBernhardt, Boris C$$b14
000910710 773__ $$0PERI:(DE-600)1483485-6$$a10.1093/cercor/bhac156$$gp. bhac156$$n5$$p1566–1580$$tCerebral cortex$$v33$$x1047-3211$$y2023
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000910710 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)173843$$a Otto Hahn group Cognitive neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences$$b4
000910710 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)173843$$a McGill University$$b4
000910710 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)173843$$a HHU Düsseldorf$$b4
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