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@ARTICLE{Hong:910710,
      author       = {Hong, Seok-Jun and Mottron, Laurent and Park, Bo-yong and
                      Benkarim, Oualid and Valk, Sofie L and Paquola, Casey and
                      Larivière, Sara and Vos de Wael, Reinder and
                      Degré-Pelletier, Janie and Soulieres, Isabelle and Ramphal,
                      Bruce and Margolis, Amy and Milham, Michael and Di Martino,
                      Adriana and Bernhardt, Boris C},
      title        = {{A} convergent structure–function substrate of cognitive
                      imbalances in autism},
      journal      = {Cerebral cortex},
      volume       = {33},
      number       = {5},
      issn         = {1047-3211},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2022-04081},
      pages        = {1566–1580},
      year         = {2023},
      note         = {Bitte Post-print ergänzen},
      abstract     = {Background: Autism spectrum disorder (ASD) is a common
                      neurodevelopmental diagnosis showing substantial phenotypic
                      heterogeneity. A leading example can be found in verbal and
                      nonverbal cognitive skills, which vary from elevated to
                      impaired compared with neurotypical individuals. Moreover,
                      deficits in verbal profiles often coexist with normal or
                      superior performance in the nonverbal domain.Methods: To
                      study brain substrates underlying cognitive imbalance in
                      ASD, we capitalized categorical and dimensional IQ profiling
                      as well as multimodal neuroimaging.Results: IQ analyses
                      revealed a marked verbal to nonverbal IQ imbalance in ASD
                      across 2 datasets (Dataset-1: 155 ASD, 151 controls;
                      Dataset-2: 270 ASD, 490 controls). Neuroimaging analysis in
                      Dataset-1 revealed a structure-function substrate of
                      cognitive imbalance, characterized by atypical cortical
                      thickening and altered functional integration of language
                      networks alongside sensory and higher cognitive
                      areas.Conclusion: Although verbal and nonverbal intelligence
                      have been considered as specifiers unrelated to autism
                      diagnosis, our results indicate that intelligence
                      disparities are accentuated in ASD and reflected by a
                      consistent structure-function substrate affecting multiple
                      brain networks. Our findings motivate the incorporation of
                      cognitive imbalances in future autism research, which may
                      help to parse the phenotypic heterogeneity and inform
                      intervention-oriented subtyping in ASD.},
      cin          = {INM-7 / INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-1-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / 5251 -
                      Multilevel Brain Organization and Variability (POF4-525) /
                      HIBALL - Helmholtz International BigBrain Analytics and
                      Learning Laboratory (HIBALL) (InterLabs-0015)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(DE-HGF)POF4-5251 /
                      G:(DE-HGF)InterLabs-0015},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35552620},
      UT           = {WOS:000793959700001},
      doi          = {10.1093/cercor/bhac156},
      url          = {https://juser.fz-juelich.de/record/910710},
}