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@ARTICLE{vanEimeren:910745,
      author       = {van Eimeren, Thilo and Drzezga, Alexander},
      title        = {{F}rom molecules to system failure: translational frontiers
                      of multimodal imaging in neurodegenerative diseases},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {46},
      number       = {13},
      issn         = {0340-6997},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {FZJ-2022-04115},
      pages        = {2816 - 2818},
      year         = {2019},
      abstract     = {Understanding the molecular and neural underpinnings of
                      neurodegenerative diseases is one of the greatest challenges
                      in today’s health-related research. To this end, the
                      translation of evidence from basic science (e.g., at the
                      molecular, cellular, or animal model level) to clinical
                      science is paramount, yet remains particularly hard to
                      achieve. Simultaneously, the plethora of evidence for the
                      clinical utility of molecular imaging has not yet lead to a
                      sufficiently available and standardized use in clinical
                      practice and there is a critical need of a
                      science-to-guidelines transition of these techniques. Both
                      tasks demand an iterative, multi-disciplinary, highly
                      collaborative approach. Following this formula, we started a
                      biannual symposium—called “Multimodal Imaging in
                      Neurodegeneration Cologne,” or short MINC—specifically
                      dedicated to bridge translational gaps in particularly
                      topical areas of research in neurodegenerative diseases. The
                      MINC symposium in October 2018 was focused on five topics:
                      the cause and effect of cerebral protein aggregation
                      pathologies (beta-amyloid, tau, and alpha-synuclein), the
                      various facets of neuroinflammation in neurodegenerative
                      diseases, non-dopaminergic transmitter dysfunction in
                      Parkinson’s disease, and the development of proteinaceous
                      agents for molecular PET imaging and for therapy. The great
                      success of this meeting was largely due to the gathering and
                      interaction of scientist from various disciplines who would
                      not usually meet at their respective science meetings. The 2
                      days of talks and discussions by experts in various fields
                      from basic to clinical science and imaging yielded many
                      intriguing insights. We have asked teams of participants of
                      the meeting to summarize the main insights from this
                      meeting. This resulted in three key chapters, which are
                      outlined below and discussed in greater depth in three
                      papers, which are published in this issue. We are extremely
                      grateful to the Deutsche Forschungsgemeinschaft (DFG) for
                      funding the MINC symposium (EI 892/5–1) and to the
                      European Journal of Nuclear Medicine and Molecular Imaging
                      for publishing these major outcomes of the MINC symposium as
                      three separate publications in this issue.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {31667539},
      UT           = {WOS:000502971900020},
      doi          = {10.1007/s00259-019-04562-7},
      url          = {https://juser.fz-juelich.de/record/910745},
}