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000910817 1001_ $$0P:(DE-HGF)0$$aEngelmann, Ulrich M.$$b0$$eCorresponding author
000910817 245__ $$aProbing particle size dependency of frequency mixing magnetic detection with dynamic relaxation simulation
000910817 260__ $$aAmsterdam$$bNorth-Holland Publ. Co.$$c2022
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000910817 520__ $$aBiomedical applications of magnetic nanoparticles (MNP) fundamentally rely on the particles’ magnetic relaxation as a response to an alternating magnetic field. The magnetic relaxation complexly depends on the interplay of MNP magnetic and physical properties with the applied field parameters. It is commonly accepted that particle core size is a major contributor to signal generation in all the above applications, however, most MNP samples comprise broad distribution spanning 10 nm and more. Therefore, precise knowledge of the exact contribution of individual core sizes to signal generation is desired for optimal MNP design generally for each application.  Specifically, we present a magnetic relaxation simulation-driven analysis of experimental frequency mixing magnetic detection (FMMD) for biosensing to quantify the contributions of individual core size fractions towards signal generation. Applying our method to two different experimental MNP systems, we found the most dominant contributions from approx. 20 nm sized particles in the two independent MNP systems. Additional comparison between freely suspended and immobilized MNP also reveals insight in the MNP microstructure, allowing to use FMMD for MNP characterization, as well as to further fine-tune its applicability in biosensing.
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000910817 7001_ $$0P:(DE-Juel1)173858$$aPourshahidi, Ali Mohammad$$b1$$ufzj
000910817 7001_ $$0P:(DE-HGF)0$$aShalaby, Ahmed$$b2
000910817 7001_ $$0P:(DE-Juel1)128697$$aKrause, Hans-Joachim$$b3$$eCorresponding author$$ufzj
000910817 773__ $$0PERI:(DE-600)1479000-2$$a10.1016/j.jmmm.2022.169965$$gVol. 563, p. 169965 -$$p169965 -$$tJournal of magnetism and magnetic materials$$v563$$x0304-8853$$y2022
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