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| Hauptseite > Publikationsdatenbank > Active Temperature Control of Magnetic Nanoparticle Samples for a Magnetic Reader with a Peltier Element |
| Hauptseite > Publikationsdatenbank > Active Temperature Control of Magnetic Nanoparticle Samples for a Magnetic Reader with a Peltier Element |
| Master Thesis | FZJ-2022-04184 |
2022
Abstract: There is no doubt that magnetic nanoparticles play a notable role in biomedical applications due to their distinctive properties. Due to their diverse applications, their precise and accurate detection is very crucial. A Magnetic Reader has been developed for the quantification of superparamagnetic iron oxide nanoparticles, based on the Frequency Mixing Magnetic Detection technique. This project aims to incorporate a temperature control system with this device. The sample is placed inside aluminium oxide (Al2O3) rod. The base of the rod is heated or cooled using a Peltier element. Temperature sensors are placed at different locations to monitor the whole system. This temperature control system is based on Proportional-Integral-Derivative (PID) control, which requires one controlling temperature sensor. Measurements were done to correlate the base of the rod with the sample position of the rod. Once the correlation is achieved, base is set as the controlling temperature sensor as other locations on the rod would have interfered with the measurement head readings. Lastly, measurements were done on a magnetic nanoparticle sample (whose concentration is determined by the calibration curve) at different temperatures. The measurement signal of frequency component f1+2·f2 was observed. The result shows an increase in amplitude and a phase drift of the same sample at different temperatures.
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